{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T20:37:45Z","timestamp":1771706265126,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":2055,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Unsupervised \u2018cluster\u2019 analysis is an invaluable tool for exploratory microarray data analysis, as it organizes the data into groups of genes or samples in which the elements share common patterns. Once the data are clustered, finding the optimal number of informative subgroups within a dataset is a problem that, while important for understanding the underlying phenotypes, is one for which there is no robust, widely accepted solution.<\/jats:p>\n               <jats:p>Results: To address this problem we developed an \u2018informativeness metric\u2019 based on a simple analysis of variance statistic that identifies the number of clusters which best separate phenotypic groups. The performance of the informativeness metric has been tested on both experimental and simulated datasets, and we contrast these results with those obtained using alternative methods such as the gap statistic.<\/jats:p>\n               <jats:p>Availability: The method has been implemented in the Bioconductor R package attract; it is also freely available from http:\/\/compbio.dfci.harvard.edu\/pubs\/attract_1.0.1.zip.<\/jats:p>\n               <jats:p>Contact: \u00a0jess@jimmy.harvard.edu; johnq@jimmy.harvard.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr074","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T01:18:15Z","timestamp":1297991895000},"page":"1094-1100","source":"Crossref","is-referenced-by-count":40,"title":["Defining an informativeness metric for clustering gene expression data"],"prefix":"10.1093","volume":"27","author":[{"given":"Jessica C.","family":"Mar","sequence":"first","affiliation":[{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"},{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Wells","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Quackenbush","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"},{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"},{"name":"1 Department of Biostatistics, Harvard School of Public Health, 2Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA, 3National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,2,16]]},"reference":[{"key":"2023061311372785700_B1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"IEEE Trans. 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