{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:39:05Z","timestamp":1775000345122,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The experimental difficulties of alpha-helical transmembrane protein structure determination make this class of protein an important target for sequence-based structure prediction tools. The MEMPACK prediction server allows users to submit a transmembrane protein sequence and returns transmembrane topology, lipid exposure, residue contacts, helix\u2013helix interactions and helical packing arrangement predictions in both plain text and graphical formats using a number of novel machine learning-based algorithms.<\/jats:p>\n               <jats:p>Availability: The server can be accessed as a new component of the PSIPRED portal by at http:\/\/bioinf.cs.ucl.ac.uk\/psipred\/.<\/jats:p>\n               <jats:p>Contact: \u00a0d.jones@cs.ucl.ac.uk; t.nugent@cs.ucl.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr096","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T01:38:20Z","timestamp":1298597900000},"page":"1438-1439","source":"Crossref","is-referenced-by-count":44,"title":["The MEMPACK alpha-helical transmembrane protein structure prediction server"],"prefix":"10.1093","volume":"27","author":[{"given":"Timothy","family":"Nugent","sequence":"first","affiliation":[{"name":"Bioinformatics Group, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Ward","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,2,23]]},"reference":[{"key":"2023012511031071600_B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023012511031071600_B2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/bioinformatics\/btl677","article-title":"Improving the accuracy of transmembrane protein topology prediction using evolutionary information","volume":"23","author":"Jones","year":"2007","journal-title":"Bioinformatics"},{"key":"2023012511031071600_B3","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/bioinformatics\/16.12.1159","article-title":"A collection of well characterised integral membrane proteins","volume":"16","author":"M\u00f6ller","year":"2000","journal-title":"Bioinformatics"},{"key":"2023012511031071600_B4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2105-10-159","article-title":"Transmembrane protein topology prediction using support vector machines","volume":"10","author":"Nugent","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2023012511031071600_B5","doi-asserted-by":"crossref","first-page":"e1000714","DOI":"10.1371\/journal.pcbi.1000714","article-title":"Predicting transmembrane helix packing arrangements using residue contacts and a force-directed algorithm","volume":"6","author":"Nugent","year":"2009","journal-title":"PLoS Comput. 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