{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:57:30Z","timestamp":1778054250473,"version":"3.51.4"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We present a tool called MRSD (Metabolic Route Search and Design) to search and design routes based on the weighted compound transform diagraph. The search submodule returns routes between a source and product compound within seconds in the network of one or multiple organisms based on data from KEGG. The design submodule designs a route from an appointed compound in an interactive mode. The two complementary functions, Metabolic Route Search and Design, can be broadly used in biosynthesis, bio-pharmaceuticals and the other related fields.<\/jats:p>\n               <jats:p>Availability: \u00a0bioinfo.ustc.edu.cn\/softwares\/MRSD\/<\/jats:p>\n               <jats:p>Contact: \u00a0hrzheng@ustc.edu.cn<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at the Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr160","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T00:31:59Z","timestamp":1301531519000},"page":"1581-1582","source":"Crossref","is-referenced-by-count":19,"title":["MRSD: a web server for Metabolic Route Search and Design"],"prefix":"10.1093","volume":"27","author":[{"given":"Deguo","family":"Xia","sequence":"first","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Zheng","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"},{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guisheng","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlong","family":"Li","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Hong","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"1 School of Computer Science and Technology and 2Department of Systems Biology, University of Science and Technology of China, Hefei 230026, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"2023012511152664200_B1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ymben.2007.08.003","article-title":"Metabolic engineering of Escherichia coli for 1-butanol production","volume":"10","author":"Atsumi","year":"2008","journal-title":"Metab. 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