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MACPAK comprises a total of 24 009 entities and 12 774 processes and is described in the Cell System Markup Language (CSML), an XML format that runs on the Cell Illustrator platform and can be visualized with a customized Cytoscape for further analysis.<\/jats:p><jats:p>Availability: MACPAK can be accessed via an interactive web site at http:\/\/macpak.csml.org. The CSML pathway models are available under the Creative Commons license.<\/jats:p><jats:p>Contact: \u00a0masao@hgc.jp<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr173","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T04:06:58Z","timestamp":1303272418000},"page":"1591-1593","source":"Crossref","is-referenced-by-count":5,"title":["Systems biology model repository for macrophage pathway simulation"],"prefix":"10.1093","volume":"27","author":[{"given":"Masao","family":"Nagasaki","sequence":"first","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Saito","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Fujita","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Tremmel","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Ueno","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euna","family":"Jeong","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Miyano","sequence":"additional","affiliation":[{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"},{"name":"1 Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108\u22128639, Japan and 2Department of Computer Science, Institute of Mathematics and Statistics, University of S\u00e3o Paulo, S\u00e3o Paulo, 05508-090, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"2023012511153818000_B1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"key":"2023012511153818000_B2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cell. 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