{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:28:40Z","timestamp":1759775320140},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: DNA methylation is a major epigenetic modification in human cells. Illumina HumanMethylation27 BeadChip makes it possible to quantify the methylation state of 27 578 loci spanning 14 495 genes. We developed a non-parametric normalization method to correct the spatial background noise in order to improve the signal-to-noise ratio. The prediction performance of the proposed method was assessed on three fully methylated samples and three fully unmethylated DNA samples. We demonstrate that the spatial normalization outperforms BeadStudio to predict the methylation state of a given locus.<\/jats:p>\n               <jats:p>Availability and Implementation: A R script and the data are available at the following address: http:\/\/bioinfo.curie.fr\/projects\/smethillium.<\/jats:p>\n               <jats:p>Contact: \u00a0smethillium@curie.fr<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr187","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T00:50:25Z","timestamp":1302828625000},"page":"1693-1695","source":"Crossref","is-referenced-by-count":9,"title":["SMETHILLIUM: spatial normalization METHod for ILLumina InfinIUM HumanMethylation BeadChip"],"prefix":"10.1093","volume":"27","author":[{"given":"Camille","family":"Sabbah","sequence":"first","affiliation":[{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"}]},{"given":"Gildas","family":"Mazo","sequence":"additional","affiliation":[{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"}]},{"given":"Caroline","family":"Paccard","sequence":"additional","affiliation":[{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"}]},{"given":"Fabien","family":"Reyal","sequence":"additional","affiliation":[{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"}]},{"given":"Philippe","family":"Hup\u00e9","sequence":"additional","affiliation":[{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue d'Ulm, Paris, F-75248"},{"name":"1 Institut Curie, 26 rue d'Ulm, F-75248, 2INSERM, U900, Paris F-75248, 3Mines ParisTech, Fontainebleau F-77300, 4CNRS UMR144, 26 rue d'Ulm, F-75248 and 5Institut Curie, Department of Surgery, 26 rue 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