{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:04:34Z","timestamp":1762898674906},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: A program package to enable genome-wide association of copy number variants (CNVs) with quantitative phenotypes in families of arbitrary size and complexity. Intensity signals that act as proxies for the number of copies are modeled in a variance component framework and association with traits is assessed through formal likelihood testing.<\/jats:p>\n               <jats:p>Availability and implementation: The Java package is made available at www.imperial.ac.uk\/medicine\/people\/m.falchi\/.<\/jats:p>\n               <jats:p>Contact: \u00a0m.falchi@imperial.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr264","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T02:18:24Z","timestamp":1304648304000},"page":"1873-1875","source":"Crossref","is-referenced-by-count":10,"title":["famCNV: copy number variant association for quantitative traits in families"],"prefix":"10.1093","volume":"27","author":[{"given":"Hariklia","family":"Eleftherohorinou","sequence":"first","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna C.","family":"Andersson-Assarsson","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"},{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin G.","family":"Walters","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"},{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia S.","family":"El-Sayed Moustafa","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachlan","family":"Coin","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jacobson","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena M. S.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra I. F.","family":"Blakemore","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Froguel","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Walley","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Falchi","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK, 2Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Gothenburg University, and Sahlgrenska Center for Cardiovascular and Metabolic Research, SE-413 07 Gothenburg, Sweden and 3Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,5,5]]},"reference":[{"key":"2023012512014915600_B1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/302698","article-title":"A general test of association for quantitative traits in nuclear families","volume":"66","author":"Abecasis","year":"2000","journal-title":"Am. 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