{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T02:34:46Z","timestamp":1746585286896},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"Abstract<\/jats:title>\n Motivation: Although genome-wide association studies (GWAS) have found many common genetic variants associated with human diseases, it remains a challenge to elucidate the functional links between associated variants and complex traits.<\/jats:p>\n Results: We developed a package called eResponseNet by implementing and extending the existing ResponseNet algorithm for prioritizing candidate disease genes through cellular pathways. Using type II diabetes (T2D) as a study case, we demonstrate that eResponseNet outperforms currently available approaches in prioritizing candidate disease genes. More importantly, the package is instrumental in revealing cellular pathways underlying disease-associated genetic variations.<\/jats:p>\n Availability: The eResponseNet package is freely downloadable at http:\/\/hanlab.genetics.ac.cn\/eResponseNet.<\/jats:p>\n Contact: \u00a0jdhan@picb.ac.cn<\/jats:p>\n Supplementary Information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr380","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T01:56:40Z","timestamp":1308880600000},"page":"2319-2320","source":"Crossref","is-referenced-by-count":9,"title":["eResponseNet: a package prioritizing candidate disease genes through cellular pathways"],"prefix":"10.1093","volume":"27","author":[{"given":"Jialiang","family":"Huang","sequence":"first","affiliation":[{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"},{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, China"}]},{"given":"Jing-Dong J.","family":"Han","sequence":"additional","affiliation":[{"name":"1 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China and 3The Graduate University of Chinese Academy of Sciences, Beijing 100062, 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