{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:36:07Z","timestamp":1775136967142,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":1898,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Mathematical modeling has a key role in systems biology. Model building is often regarded as an iterative loop involving several tasks, among which the estimation of unknown parameters of the model from a certain set of experimental data is of central importance. This problem of parameter estimation has many possible pitfalls, and modelers should be very careful to avoid them. Many of such difficulties arise from a fundamental (yet often overlooked) property: the so-called structural (or a priori) identifiability, which considers the uniqueness of the estimated parameters. Obviously, the structural identifiability of any tentative model should be checked at the beginning of the model building loop. However, checking this property for arbitrary non-linear dynamic models is not an easy task. Here we present a software toolbox, GenSSI (Generating Series for testing Structural Identifiability), which enables non-expert users to carry out such analysis. The toolbox runs under the popular MATLAB environment and is accompanied by detailed documentation and relevant examples.<\/jats:p>\n               <jats:p>Availability: The GenSSI toolbox and the related documentation are available at http:\/\/www.iim.csic.es\/%7Egenssi.<\/jats:p>\n               <jats:p>Contact: \u00a0ebalsa@iim.csic.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr431","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T04:30:30Z","timestamp":1311395430000},"page":"2610-2611","source":"Crossref","is-referenced-by-count":110,"title":["GenSSI: a software toolbox for structural identifiability analysis of biological models"],"prefix":"10.1093","volume":"27","author":[{"given":"Oana","family":"Chi\u015f","sequence":"first","affiliation":[{"name":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208 Vigo, Spain"}]},{"given":"Julio R.","family":"Banga","sequence":"additional","affiliation":[{"name":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208 Vigo, Spain"}]},{"given":"Eva","family":"Balsa-Canto","sequence":"additional","affiliation":[{"name":"(Bio)Process Engineering Group, Spanish National Research Council, IIM-CSIC, 36208 Vigo, Spain"}]}],"member":"286","published-online":{"date-parts":[[2011,7,22]]},"reference":[{"key":"2023012512004140700_B1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.1742-4658.2008.06844.x","article-title":"Systems biology: parameter estimation for biochemical models","volume":"276","author":"Ashyraliyev","year":"2009","journal-title":"FEBS J."},{"key":"2023012512004140700_B2","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btr370","article-title":"AMIGO, a toolbox for advanced model identification in systems biology using global optimization","author":"Balsa-Canto","year":"2011","journal-title":"Bioinformatics"},{"key":"2023012512004140700_B3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1752-0509-4-11","article-title":"An iterative identification procedure for dynamic modeling of biochemical networks","volume":"4","author":"Balsa-Canto","year":"2010","journal-title":"BMC Syst. Biol."},{"key":"2023012512004140700_B4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/bse0450195","article-title":"Parameter estimation and optimal experimental design","volume":"45","author":"Banga","year":"2008","journal-title":"Essays Biochem."},{"key":"2023012512004140700_B5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cmpb.2007.07.002","article-title":"DAISY: a new software tool to test global identifiability of biological and physiological systems","volume":"88","author":"Bellu","year":"2007","journal-title":"Comp. Meth. Prog. Biomed."},{"key":"2023012512004140700_B6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2030","article-title":"Linking data to models: data regression","volume":"7","author":"Jaqaman","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023012512004140700_B7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0005-1098(94)90029-9","article-title":"On global identifiability for arbitrary model parametrizations","volume":"30","author":"Ljung","year":"1994","journal-title":"Automatica"},{"key":"2023012512004140700_B8","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/bioinformatics\/btp358","article-title":"Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood","volume":"25","author":"Raue","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012512004140700_B9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jbiotec.2010.02.019","article-title":"Parameter identifiability of power-law biochemical system models","volume":"149","author":"Srinath","year":"2010","journal-title":"J. Biotech."},{"key":"2023012512004140700_B10","article-title":"Identification of parametric models from experimental data","volume-title":"Commun. Control Eng. ed.","author":"Walter","year":"1997"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/18\/2610\/48868444\/bioinformatics_27_18_2610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/18\/2610\/48868444\/bioinformatics_27_18_2610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T13:55:03Z","timestamp":1674654903000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/27\/18\/2610\/181190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,22]]},"references-count":10,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2011,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btr431","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,9,15]]},"published":{"date-parts":[[2011,7,22]]}}}