{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:59:46Z","timestamp":1771235986507,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: \u00a0In vivo dynamic contrast-enhanced imaging tools provide non-invasive methods for analyzing various functional changes associated with disease initiation, progression and responses to therapy. The quantitative application of these tools has been hindered by its inability to accurately resolve and characterize targeted tissues due to spatially mixed tissue heterogeneity. Convex Analysis of Mixtures \u2013 Compartment Modeling (CAM-CM) signal deconvolution tool has been developed to automatically identify pure-volume pixels located at the corners of the clustered pixel time series scatter simplex and subsequently estimate tissue-specific pharmacokinetic parameters. CAM-CM can dissect complex tissues into regions with differential tracer kinetics at pixel-wise resolution and provide a systems biology tool for defining imaging signatures predictive of phenotypes.<\/jats:p>\n               <jats:p>Availability: The MATLAB source code can be downloaded at the authors\u2032 website www.cbil.ece.vt.edu\/software.htm<\/jats:p>\n               <jats:p>Contact: \u00a0yuewang@vt.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr436","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T00:35:44Z","timestamp":1311467744000},"page":"2607-2609","source":"Crossref","is-referenced-by-count":27,"title":["CAM-CM: a signal deconvolution tool for <i>in vivo<\/i> dynamic contrast-enhanced imaging of complex tissues"],"prefix":"10.1093","volume":"27","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[{"name":"1 Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, 2Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, 3Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, 4Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, 5Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, 6School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and 7Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Han","family":"Chan","sequence":"additional","affiliation":[{"name":"1 Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, 2Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, 3Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, 4Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, 5Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, 6School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and 7Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA"},{"name":"1 Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, 2Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, 3Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, 4Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, 5Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, 6School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and 7Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Choyke","sequence":"additional","affiliation":[{"name":"1 Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, 2Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, 3Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, 4Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, 5Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, 6School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and 7Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M. 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