{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:52:03Z","timestamp":1783727523826,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1848,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: SPREAD is a user-friendly, cross-platform application to analyze and visualize Bayesian phylogeographic reconstructions incorporating spatial\u2013temporal diffusion. The software maps phylogenies annotated with both discrete and continuous spatial information and can export high-dimensional posterior summaries to keyhole markup language (KML) for animation of the spatial diffusion through time in virtual globe software. In addition, SPREAD implements Bayes factor calculation to evaluate the support for hypotheses of historical diffusion among pairs of discrete locations based on Bayesian stochastic search variable selection estimates. SPREAD takes advantage of multicore architectures to process large joint posterior distributions of phylogenies and their spatial diffusion and produces visualizations as compelling and interpretable statistical summaries for the different spatial projections.<\/jats:p>\n               <jats:p>Availability: SPREAD is licensed under the GNU Lesser GPL and its source code is freely available as a GitHub repository: https:\/\/github.com\/phylogeography\/SPREAD<\/jats:p>\n               <jats:p>Contact: \u00a0filip.bielejec@rega.kuleuven.be<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr481","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T04:22:25Z","timestamp":1315887745000},"page":"2910-2912","source":"Crossref","is-referenced-by-count":462,"title":["SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics"],"prefix":"10.1093","volume":"27","author":[{"given":"Filip","family":"Bielejec","sequence":"first","affiliation":[{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rambaut","sequence":"additional","affiliation":[{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"},{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Suchard","sequence":"additional","affiliation":[{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"},{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"},{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lemey","sequence":"additional","affiliation":[{"name":"1 Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, 2Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, 3Fogarty International Center, National Institutes of Health, Bethesda, MD, 4Department of Biomathematics, 5Department of Biostatistics and 6Department of Human Genetics, University of California, Los Angeles, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,11]]},"reference":[{"key":"2023012512013615500_B1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tree.2010.08.010","article-title":"Three roads diverged? 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