{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:21Z","timestamp":1747185081188},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Abstract: Computer simulation models can be useful in exploring the efficacy of HIV therapy regimens in preventing the evolution of drug-resistant viruses. Current modeling programs, however, were designed by researchers with expertise in computational biology, limiting their accessibility to those who might lack such a background. We have developed a user-friendly graphical program, HIV Therapy Simulator (HIVSIM), that is accessible to non-technical users. The program allows clinicians and researchers to explore the effectiveness of various therapeutic strategies, such as structured treatment interruptions, booster therapies and induction-maintenance therapies. We anticipate that HIVSIM will be useful for evaluating novel drug-based treatment concepts in clinical research, and as an educational tool.<\/jats:p>\n               <jats:p>Availability: HIV Therapy Simulator is freely available for Mac OS and Windows at http:\/\/sites.google.com\/site\/hivsimulator\/.<\/jats:p>\n               <jats:p>Contact: \u00a0jmittler@uw.edu<\/jats:p>\n               <jats:p>Supplementary Information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr515","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T04:29:25Z","timestamp":1315628965000},"page":"3065-3066","source":"Crossref","is-referenced-by-count":4,"title":["HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens"],"prefix":"10.1093","volume":"27","author":[{"given":"Huat Chye","family":"Lim","sequence":"first","affiliation":[{"name":"1 Department of Microbiology and 2Department of Medicine, University of Washington, Seattle, WA 98195, USA"}]},{"given":"Marcel E.","family":"Curlin","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology and 2Department of Medicine, University of Washington, Seattle, WA 98195, USA"}]},{"given":"John E.","family":"Mittler","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology and 2Department of Medicine, University of Washington, Seattle, WA 98195, USA"}]}],"member":"286","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"2023012511342482500_B1","doi-asserted-by":"crossref","first-page":"6971","DOI":"10.1073\/pnas.94.13.6971","article-title":"Virus dynamics and drug therapy","volume":"94","author":"Bonhoeffer","year":"1997","journal-title":"Proc. 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