{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:46:52Z","timestamp":1762098412503},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1822,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Analysing large amounts of data generated by next-generation sequencing (NGS) technologies is difficult for researchers or clinicians without computational skills. They are often compelled to delegate this task to computer biologists working with command line utilities. The availability of easy-to-use tools will become essential with the generalization of NGS in research and diagnosis. It will enable investigators to handle much more of the analysis. Here, we describe Knime4Bio, a set of custom nodes for the KNIME (The Konstanz Information Miner) interactive graphical workbench, for the interpretation of large biological datasets. We demonstrate that this tool can be utilized to quickly retrieve previously published scientific findings.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/code.google.com\/p\/knime4bio\/.<\/jats:p>\n               <jats:p>Contact: \u00a0richard.redon@univ-nantes.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr554","type":"journal-article","created":{"date-parts":[[2011,10,8]],"date-time":"2011-10-08T02:49:40Z","timestamp":1318042180000},"page":"3200-3201","source":"Crossref","is-referenced-by-count":23,"title":["Knime4Bio: a set of custom nodes for the interpretation of next-generation sequencing data with KNIME"],"prefix":"10.1093","volume":"27","author":[{"given":"Pierre","family":"Lindenbaum","sequence":"first","affiliation":[{"name":"1 Institut du thorax, Inserm UMR 915, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France and 2The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"}]},{"given":"Solena","family":"Le Scouarnec","sequence":"additional","affiliation":[{"name":"1 Institut du thorax, Inserm UMR 915, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France and 2The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"}]},{"given":"Vincent","family":"Portero","sequence":"additional","affiliation":[{"name":"1 Institut du thorax, Inserm UMR 915, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France and 2The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"}]},{"given":"Richard","family":"Redon","sequence":"additional","affiliation":[{"name":"1 Institut du thorax, Inserm UMR 915, Centre Hospitalier Universitaire de Nantes, 44000 Nantes, France and 2The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"}]}],"member":"286","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"2023012511334695500_B1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. 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Mutat."},{"key":"2023012511334695500_B12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012511334695500_B13","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012511334695500_B14","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/bioinformatics\/btq671","article-title":"Tabix: fast retrieval of sequence features from generic TAB-delimited files","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"2023012511334695500_B15","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/bioinformatics\/btp493","article-title":"Mobyle: a new full web bioinformatics framework","volume":"25","author":"Nron","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012511334695500_B16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1101\/gr.176601","article-title":"Predicting deleterious amino acid substitutions","volume":"11","author":"Ng","year":"2001","journal-title":"Genome Res."},{"key":"2023012511334695500_B17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"2023012511334695500_B18","doi-asserted-by":"crossref","first-page":"D358","DOI":"10.1093\/nar\/gkl825","article-title":"STRING 7\u2013recent developments in the integration and prediction of protein interactions","volume":"35","author":"von Mering","year":"2007","journal-title":"Nucleic Acids Res."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/22\/3200\/48863532\/bioinformatics_27_22_3200.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/22\/3200\/48863532\/bioinformatics_27_22_3200.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:36:10Z","timestamp":1674646570000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/27\/22\/3200\/196060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,7]]},"references-count":18,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2011,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btr554","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,11,15]]},"published":{"date-parts":[[2011,10,7]]}}}