{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:32:49Z","timestamp":1767961969894,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The interaction between genetic factors and environmental factors has critical roles in determining the phenotype of an organism. In recent years, a number of studies have reported that the dysfunctions on microRNA (miRNAs), environmental factors and their interactions have strong effects on phenotypes and even may result in abnormal phenotypes and diseases, whereas there has been no a database linking miRNAs, environmental factors and phenotypes. Such a resource platform is believed to be of great value in the understanding of miRNAs, environmental factors, especially drugs and diseases. In this study, we constructed the miREnvironment database, which contains a comprehensive collection and curation of experimentally supported interactions among miRNAs, environmental factors and phenotypes. The names of miRNAs, phenotypes, environmental factors, conditions of environmental factors, samples, species, evidence and references were further annotated. miREnvironment represents a biomedical resource for researches on miRNAs, environmental factors and diseases.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/cmbi.bjmu.edu.cn\/miren.<\/jats:p>\n               <jats:p>Contact: \u00a0cuiqinghua@hsc.pku.edu.cn<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr556","type":"journal-article","created":{"date-parts":[[2011,10,8]],"date-time":"2011-10-08T02:49:40Z","timestamp":1318042180000},"page":"3329-3330","source":"Crossref","is-referenced-by-count":69,"title":["miREnvironment Database: providing a bridge for microRNAs, environmental factors and phenotypes"],"prefix":"10.1093","volume":"27","author":[{"given":"Qingqing","family":"Yang","sequence":"first","affiliation":[{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"},{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"}]},{"given":"Chengxiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"},{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"}]},{"given":"Qinghua","family":"Cui","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"},{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"},{"name":"1 Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, 2School of Computer Science, Hebei University of Technology, Tianjin 300401, 3Institute of Systems Biomedicine and 4MOE Key Lab of Molecular Cardiovascular Science, Peking University, Beijing 100191, China"}]}],"member":"286","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"2023012511112961400_B1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/labinvest.2010.166","article-title":"Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease","volume":"91","author":"Alisi","year":"2011","journal-title":"Lab. Invest."},{"key":"2023012511112961400_B2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2023012511112961400_B3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1590\/S0004-27302009000500008","article-title":"Vitamins and minerals with antioxidant properties and cardiometabolic risk: controversies and perspectives","volume":"53","author":"Catania","year":"2009","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"2023012511112961400_B4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrurol.2010.46","article-title":"Epidemiology and risk factors for kidney cancer","volume":"7","author":"Chow","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"2023012511112961400_B5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nut.2009.09.020","article-title":"Obesity: genes, brain, gut, and environment","volume":"26","author":"Das","year":"2010","journal-title":"Nutrition"},{"key":"2023012511112961400_B6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2023012511112961400_B7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3892\/mmr_00000279","article-title":"Influence of stress and health-behaviour on miRNA expression","volume":"3","author":"Gidron","year":"2010","journal-title":"Mol. Med. Report"},{"key":"2023012511112961400_B8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/carcin\/bgq037","article-title":"Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung","volume":"31","author":"Izzotti","year":"2010","journal-title":"Carcinogenesis"},{"key":"2023012511112961400_B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrfmmm.2011.03.014","article-title":"microRNAs: implications for air pollution research","author":"Jardim","year":"2011","journal-title":"Mutat Res."},{"key":"2023012511112961400_B10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ajh.2009.251","article-title":"Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database","volume":"23","author":"Kitsios","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"2023012511112961400_B11","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/hep.22256","article-title":"MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene\/tumor suppressor gene mutations","volume":"47","author":"Ladeiro","year":"2008","journal-title":"Hepatology"},{"key":"2023012511112961400_B12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejca.2010.11.005","article-title":"MicroRNA regulation of core apoptosis pathways in cancer","volume":"47","author":"Lima","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"2023012511112961400_B13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.canlet.2010.08.018","article-title":"miRNAs in the pathogenesis of oncogenic human viruses","volume":"305","author":"Lin","year":"2011","journal-title":"Cancer Lett."},{"key":"2023012511112961400_B14","doi-asserted-by":"crossref","first-page":"e3420","DOI":"10.1371\/journal.pone.0003420","article-title":"An analysis of human microRNA and disease associations","volume":"3","author":"Lu","year":"2008","journal-title":"PLoS One"},{"key":"2023012511112961400_B15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/toxsci\/kfl008","article-title":"The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks","volume":"92","author":"Mattingly","year":"2006","journal-title":"Toxicol. Sci."},{"key":"2023012511112961400_B16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1748-717X-6-29","article-title":"MicroRNA expression profiles in human cancer cells after ionizing radiation","volume":"6","author":"Niemoeller","year":"2011","journal-title":"Radiat. Oncol."},{"key":"2023012511112961400_B17","doi-asserted-by":"crossref","first-page":"96ra77","DOI":"10.1126\/scitranslmed.3001318","article-title":"Discovery and preclinical validation of drug indications using compendia of public gene expression data","volume":"3","author":"Sirota","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"2023012511112961400_B18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrendo.2010.87","article-title":"Environmental causes of cancer: endocrine disruptors as carcinogens","volume":"6","author":"Soto","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"2023012511112961400_B19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2288-10-107","article-title":"A methodology to establish a database to study gene environment interactions for childhood asthma","volume":"10","author":"Turner","year":"2010","journal-title":"BMC Med. Res. Methodol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/23\/3329\/48861204\/bioinformatics_27_23_3329.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/27\/23\/3329\/48861204\/bioinformatics_27_23_3329.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:13:46Z","timestamp":1674645226000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/27\/23\/3329\/235063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,7]]},"references-count":19,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btr556","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,12,1]]},"published":{"date-parts":[[2011,10,7]]}}}