{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T01:35:33Z","timestamp":1722821733958},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: There have been several studies on the micro-inversions between human and chimpanzee, but there are large discrepancies among their results. Furthermore, all of them rely on alignment procedures or existing alignment results to identify inversions. However, the core alignment procedures do not take very small inversions into consideration. Therefore, their analyses cannot find inversions that are too small to be detected by a classic aligner. We call such inversions pico-inversions.<\/jats:p>\n               <jats:p>Results: We re-analyzed human\u2013chimpanzee alignment from the UCSC Genome Browser for micro-inplace-inversions and screened for pico-inplace-inversions using a likelihood ratio test. We report that the quantity of inplace-inversions between human and chimpanzee is substantially greater than what had previously been discovered. We also present the software tool PicoInversionMiner to detect pico-inplace-inversions between closely related species.<\/jats:p>\n               <jats:p>Availability: Software tools, scripts and result data are available at http:\/\/faculty.cs.niu.edu\/~hou\/PicoInversion.html.<\/jats:p>\n               <jats:p>Contact: \u00a0mhou@cs.niu.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr566","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:14:29Z","timestamp":1318464869000},"page":"3266-3275","source":"Crossref","is-referenced-by-count":7,"title":["Pico-inplace-inversions between human and chimpanzee"],"prefix":"10.1093","volume":"27","author":[{"given":"Minmei","family":"Hou","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, 2School of Nursing and Health Studies, 3Department of Mathematical Sciences and 4Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA"}]},{"given":"Ping","family":"Yao","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Nursing and Health Studies, 3Department of Mathematical Sciences and 4Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA"}]},{"given":"Angela","family":"Antonou","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Nursing and Health Studies, 3Department of Mathematical Sciences and 4Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA"}]},{"given":"Mitrick A.","family":"Johns","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Nursing and Health Studies, 3Department of Mathematical Sciences and 4Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA"}]}],"member":"286","published-online":{"date-parts":[[2011,10,12]]},"reference":[{"key":"2023012511050925400_B1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1101\/gr.5774507","article-title":"Evidence for large inversion polymorphisms in the human genome from HapMap data","volume":"17","author":"Bansal","year":"2007","journal-title":"Genome Res."},{"key":"2023012511050925400_B2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gr.1933104","article-title":"Aligning multiple genomic sequences with the threaded blockset aligner","volume":"14","author":"Blanchette","year":"2004","journal-title":"Genome Res."},{"key":"2023012511050925400_B3","first-page":"26","article-title":"Genome-scale evolution: reconstructing gene orders in the ancestral species","volume":"12","author":"Bourque","year":"2002","journal-title":"Genome Res."},{"key":"2023012511050925400_B4","doi-asserted-by":"crossref","first-page":"19824","DOI":"10.1073\/pnas.0603984103","article-title":"Microinversions in mammalian evolution","volume":"103","author":"Chaisson","year":"2006","journal-title":"Proc. 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