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A modular model specification allows for straightforward creation of large-scale models containing many compartments and reactions. Models are simulated either using stochastic simulation or numerical integration, and visualized in time and space. Model parameters and structure can be optimized with evolutionary algorithms, and model properties calculated using probabilistic model checking.<\/jats:p>\n               <jats:p>Availability: Source code and binaries for Linux, Mac and Windows are available at http:\/\/www.infobiotics.org\/infobiotics-workbench\/; released under the GNU General Public License (GPL) version 3.<\/jats:p>\n               <jats:p>Contact: \u00a0Natalio.Krasnogor@nottingham.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr571","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:14:29Z","timestamp":1318464869000},"page":"3323-3324","source":"Crossref","is-referenced-by-count":34,"title":["The Infobiotics Workbench: an integrated <i>in silico<\/i> modelling platform for Systems and Synthetic Biology"],"prefix":"10.1093","volume":"27","author":[{"given":"Jonathan","family":"Blakes","sequence":"first","affiliation":[{"name":"1 Automated Scheduling, Optimisation and Planning Group, School of Computer Science, University of Nottingham, Nottingham, NG8 1BB, 2The Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, LE12 5RD, UK and 3Department of Computer Science and Artificial Intelligence, University of Seville, 41012, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Twycross","sequence":"additional","affiliation":[{"name":"1 Automated Scheduling, Optimisation and Planning Group, School of Computer Science, University of Nottingham, Nottingham, NG8 1BB, 2The Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, LE12 5RD, UK and 3Department of Computer Science and Artificial Intelligence, University of Seville, 41012, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jose","family":"Romero\u2212Campero","sequence":"additional","affiliation":[{"name":"1 Automated Scheduling, Optimisation and Planning Group, School of Computer Science, University of Nottingham, Nottingham, NG8 1BB, 2The Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, LE12 5RD, UK and 3Department of Computer Science and Artificial Intelligence, University of Seville, 41012, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Krasnogor","sequence":"additional","affiliation":[{"name":"1 Automated Scheduling, Optimisation and Planning Group, School of Computer Science, University of Nottingham, Nottingham, NG8 1BB, 2The Centre for Plant Integrative Biology, School of Biosciences, University of Nottingham, LE12 5RD, UK and 3Department of Computer Science and Artificial Intelligence, University of Seville, 41012, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,10,12]]},"reference":[{"key":"2023012511112411100_B1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11693-009-9050-7","article-title":"Evolving cell models for systems and synthetic biology","volume":"4","author":"Cao","year":"2010","journal-title":"Syst. 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