{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:23:24Z","timestamp":1776169404561,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1806,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Sequencing pooled DNA samples (Pool-Seq) is the most cost-effective approach for the genome-wide comparison of population samples. Here, we introduce PoPoolation2, the first software tool specifically designed for the comparison of populations with Pool-Seq data. PoPoolation2 implements a range of commonly used measures of differentiation (FST, Fisher's exact test and Cochran-Mantel-Haenszel test) that can be applied on different scales (windows, genes, exons, SNPs). The result may be visualized with the widely used Integrated Genomics Viewer.<\/jats:p>\n               <jats:p>Availability and Implementation: PoPoolation2 is implemented in Perl and R. It is freely available on http:\/\/code.google.com\/p\/popoolation2\/<\/jats:p>\n               <jats:p>Contact: \u00a0christian.schloetterer@vetmeduni.ac.at<\/jats:p>\n               <jats:p>Supplementary Information: Manual: http:\/\/code.google.com\/p\/popoolation2\/wiki\/Manual Test data and tutorial: http:\/\/code.google.com\/p\/popoolation2\/wiki\/Tutorial Validation: http:\/\/code.google.com\/p\/popoolation2\/wiki\/Validation<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr589","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T00:58:42Z","timestamp":1319504322000},"page":"3435-3436","source":"Crossref","is-referenced-by-count":803,"title":["PoPoolation2: identifying differentiation between populations using sequencing of pooled DNA samples (Pool-Seq)"],"prefix":"10.1093","volume":"27","author":[{"given":"Robert","family":"Kofler","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Populationsgenetik, Vetmeduni Vienna, Veterin\u00e4rplatz 1, A-1210 Wien, Austria"}]},{"given":"Ram Vinay","family":"Pandey","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Populationsgenetik, Vetmeduni Vienna, Veterin\u00e4rplatz 1, A-1210 Wien, Austria"}]},{"given":"Christian","family":"Schl\u00f6tterer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Populationsgenetik, Vetmeduni Vienna, Veterin\u00e4rplatz 1, A-1210 Wien, Austria"}]}],"member":"286","published-online":{"date-parts":[[2011,10,23]]},"reference":[{"key":"2023012511310484100_B1","doi-asserted-by":"crossref","first-page":"i318","DOI":"10.1093\/bioinformatics\/btq214","article-title":"A statistical method for the detection of variants from next-generation resequencing of DNA pools","volume":"26","author":"Bansal","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012511310484100_B2","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1371\/journal.pbio.0050310","article-title":"Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans","volume":"5","author":"Begun","year":"2007","journal-title":"PLoS Biol."},{"key":"2023012511310484100_B3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature09352","article-title":"Genome-wide analysis of a long-term evolution experiment with Drosophila","volume":"467","author":"Burke","year":"2010","journal-title":"Nature"},{"key":"2023012511310484100_B4","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/genetics\/138.4.1365","article-title":"Selective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus","volume":"138","author":"Darvasi","year":"1994","journal-title":"Genetics"},{"key":"2023012511310484100_B5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1755-0998.2010.02847.x","article-title":"Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows","volume":"10","author":"Excoffier","year":"2010","journal-title":"Mol. 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