{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:56:45Z","timestamp":1696633005257},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Many protein\u2013protein interactions are more complex than can be accounted for by 1:1 binding models. However, biochemists have few tools available to help them recognize and predict the behaviors of these more complicated systems, making it difficult to design experiments that distinguish between possible binding models. MTBindingSim provides researchers with an environment in which they can rapidly compare different models of binding for a given scenario. It is written specifically with microtubule polymers in mind, but many of its models apply equally well to any polymer or any protein\u2013protein interaction. MTBindingSim can thus both help in training intuition about binding models and with experimental design.<\/jats:p>\n               <jats:p>Availability and implementation: MTBindingSim is implemented in MATLAB and runs either within MATLAB (on Windows, Mac or Linux) or as a binary without MATLAB (on Windows or Mac). The source code (licensed under the GNU General Public License) and binaries are freely available at http:\/\/mtbindingsim.googlecode.com.<\/jats:p>\n               <jats:p>Contact: \u00a0jphilip@nd.edu; cpence@nd.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr684","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T02:00:11Z","timestamp":1323914411000},"page":"441-443","source":"Crossref","is-referenced-by-count":3,"title":["MTBindingSim: simulate protein binding to microtubules"],"prefix":"10.1093","volume":"28","author":[{"given":"Julia T.","family":"Philip","sequence":"first","affiliation":[{"name":"1 Department of Chemistry and Biochemistry and 2Program in History and Philosophy of Science, University of Notre Dame, Notre Dame, IN 46556, USA"}]},{"given":"Charles H.","family":"Pence","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry and Biochemistry and 2Program in History and Philosophy of Science, University of Notre Dame, Notre Dame, IN 46556, USA"}]},{"given":"Holly V.","family":"Goodson","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry and Biochemistry and 2Program in History and Philosophy of Science, University of Notre Dame, Notre Dame, IN 46556, USA"}]}],"member":"286","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"2023012512165325800_B1","doi-asserted-by":"crossref","first-page":"30335","DOI":"10.1074\/jbc.M002590200","article-title":"Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation","volume":"275","author":"Ackman","year":"2000","journal-title":"J. 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