{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:12:57Z","timestamp":1761743577384},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: microRibonucleic acid (miRNAs) are small regulatory molecules that act by mRNA degradation or via translational repression. Although many miRNAs are ubiquitously expressed, a small subset have differential expression patterns that may give rise to tissue-specific complexes.<\/jats:p>\n               <jats:p>Motivation: This work studies gene targeting patterns amongst miRNAs with differential expression profiles, and links this to control and regulation of protein complexes.<\/jats:p>\n               <jats:p>Results: We find that, when a pair of miRNAs are not expressed in the same tissues, there is a higher tendency for them to target the direct partners of the same hub proteins. At the same time, they also avoid targeting the same set of hub-spokes. Moreover, the complexes corresponding to these hub-spokes tend to be specific and nonoverlapping. This suggests that the effect of miRNAs on the formation of complexes is specific.<\/jats:p>\n               <jats:p>Contact: \u00a0wongls@comp.nus.edu.sg<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr693","type":"journal-article","created":{"date-parts":[[2011,12,18]],"date-time":"2011-12-18T01:44:35Z","timestamp":1324172675000},"page":"453-456","source":"Crossref","is-referenced-by-count":15,"title":["The role of miRNAs in complex formation and control"],"prefix":"10.1093","volume":"28","author":[{"given":"Wilson Wen Bin","family":"Goh","sequence":"first","affiliation":[{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"}]},{"given":"Hirotaka","family":"Oikawa","sequence":"additional","affiliation":[{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"}]},{"given":"Judy Chia Ghee","family":"Sng","sequence":"additional","affiliation":[{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"},{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"}]},{"given":"Marek","family":"Sergot","sequence":"additional","affiliation":[{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"}]},{"given":"Limsoon","family":"Wong","sequence":"additional","affiliation":[{"name":"1 Department of Computing, Imperial College London, London, UK, 2Singapore Institute for Clinical Sciences, A*STAR, 3Department of Physiology and 4Department of Computer Science, National University of Singapore, Singapore"}]}],"member":"286","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"2023012512181632900_B1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.286.5439.509","article-title":"Emergence of scaling in random networks","volume":"286","author":"Barabasi","year":"1999","journal-title":"Science"},{"key":"2023012512181632900_B2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1101\/gad.381706","article-title":"Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions","volume":"20","author":"Bracken","year":"2006","journal-title":"Genes Dev."},{"key":"2023012512181632900_B3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn. 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