{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:04:00Z","timestamp":1775117040795,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles.<\/jats:p>\n               <jats:p>Availability: Both source and binary software packages are available at http:\/\/www.niehs.nih.gov\/research\/resources\/software\/art<\/jats:p>\n               <jats:p>Contact: \u00a0weichun.huang@nih.gov; gabor.marth@bc.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btr708","type":"journal-article","created":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T01:23:15Z","timestamp":1324776195000},"page":"593-594","source":"Crossref","is-referenced-by-count":1425,"title":["ART: a next-generation sequencing read simulator"],"prefix":"10.1093","volume":"28","author":[{"given":"Weichun","family":"Huang","sequence":"first","affiliation":[{"name":"1 Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and 2Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA"}]},{"given":"Leping","family":"Li","sequence":"additional","affiliation":[{"name":"1 Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and 2Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA"}]},{"given":"Jason R.","family":"Myers","sequence":"additional","affiliation":[{"name":"1 Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and 2Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA"}]},{"given":"Gabor T.","family":"Marth","sequence":"additional","affiliation":[{"name":"1 Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and 2Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA"}]}],"member":"286","published-online":{"date-parts":[[2011,12,23]]},"reference":[{"key":"2023012512192718500_B1","doi-asserted-by":"crossref","first-page":"i420","DOI":"10.1093\/bioinformatics\/btq365","article-title":"Characteristics of 454 pyrosequencing data\u2013enabling realistic simulation with flowsim","volume":"26","author":"Balzer","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012512192718500_B2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.gde.2006.10.009","article-title":"Whole-genome re-sequencing","volume":"16","author":"Bentley","year":"2006","journal-title":"Curr. 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