{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:31:54Z","timestamp":1742358714389,"version":"3.40.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1726,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: The deluge of data emerging from high-throughput sequencing technologies poses large analytical challenges when testing for association to disease. We introduce a scalable framework for variable selection, implemented in C++ and OpenCL, that fits regularized regression across multiple Graphics Processing Units. Open source code and documentation can be found at a Google Code repository under the URL http:\/\/bioinformatics.oxfordjournals.org\/content\/early\/2012\/01\/10\/bioinformatics.bts015.abstract.<\/jats:p><jats:p>Contact: \u00a0gary.k.chen@usc.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts015","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T03:10:30Z","timestamp":1326337830000},"page":"719-720","source":"Crossref","is-referenced-by-count":7,"title":["A scalable and portable framework for massively parallel variable selection in genetic association studies"],"prefix":"10.1093","volume":"28","author":[{"given":"Gary K.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Biostatistics, Department of Preventive Medicine, 2001 North Soto Street Los Angeles, CA 90089, USA"}]}],"member":"286","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"2023012512193023400_B1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1214\/009053604000000067","article-title":"Least angle regression","volume":"32","author":"Efron","year":"2004","journal-title":"Ann. Statist."},{"key":"2023012512193023400_B2","first-page":"1","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softwr."},{"key":"2023012512193023400_B3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/ng.839","article-title":"Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21","volume":"43","author":"Haiman","year":"2011","journal-title":"Nat. Genet."},{"key":"2023012512193023400_B4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1467-9868.2010.00740.x","article-title":"Stability selection","volume":"72","author":"Meinshausen","year":"2010","journal-title":"J. R. Stat. Soc. Ser. B"},{"issue":"Suppl. 1","key":"2023012512193023400_B5","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2350-8-S1-S6","article-title":"A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study","volume":"8","author":"Murabito","year":"2007","journal-title":"BMC Med. Genet."},{"key":"2023012512193023400_B6","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1093\/hmg\/ddr295","article-title":"Genome-wide association study identifies new prostate cancer susceptibility loci","volume":"20","author":"Schumacher","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2023012512193023400_B7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"2023012512193023400_B8","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/bioinformatics\/btq448","article-title":"Association screening of common and rare genetic variants by penalized regression","volume":"26","author":"Zhou","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/5\/719\/48880223\/bioinformatics_28_5_719.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/5\/719\/48880223\/bioinformatics_28_5_719.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T18:56:26Z","timestamp":1742324186000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/28\/5\/719\/248080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,11]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bts015","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"type":"electronic","value":"1367-4811"},{"type":"print","value":"1367-4803"}],"subject":[],"published-other":{"date-parts":[[2012,3,1]]},"published":{"date-parts":[[2012,1,11]]}}}