{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:29:22Z","timestamp":1767853762020,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1694,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The identification of orthologs\u2014genes pairs descended from a common ancestor through speciation, rather than duplication\u2014has emerged as an essential component of many bioinformatics applications, ranging from the annotation of new genomes to experimental target prioritization. Yet, the development and application of orthology inference methods is hampered by the lack of consensus on source proteomes, file formats and benchmarks. The second \u2018Quest for Orthologs\u2019 meeting brought together stakeholders from various communities to address these challenges. We report on achievements and outcomes of this meeting, focusing on topics of particular relevance to the research community at large. The Quest for Orthologs consortium is an open community that welcomes contributions from all researchers interested in orthology research and applications.<\/jats:p>\n               <jats:p>Contact: \u00a0dessimoz@ebi.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts050","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T01:23:09Z","timestamp":1329182589000},"page":"900-904","source":"Crossref","is-referenced-by-count":74,"title":["Toward community standards in the quest for orthologs"],"prefix":"10.1093","volume":"28","author":[{"given":"Christophe","family":"Dessimoz","sequence":"first","affiliation":[{"name":"1 ETH Zurich and Swiss Institute of Bioinformatics, Universit\u00e4tstrasse 6, 8092 Z\u00fcrich, Switzerland, 2Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), and UPF. Dr. Aiguader, 88, 08003 Barcelona, Spain, 3Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA, 4Stockholm Bioinformatics Center, Swedish eScience Research Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, 5European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Toni","family":"Gabald\u00f3n","sequence":"additional","affiliation":[{"name":"1 ETH Zurich and Swiss Institute of Bioinformatics, Universit\u00e4tstrasse 6, 8092 Z\u00fcrich, Switzerland, 2Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), and UPF. Dr. Aiguader, 88, 08003 Barcelona, Spain, 3Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA, 4Stockholm Bioinformatics Center, Swedish eScience Research Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, 5European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"David S.","family":"Roos","sequence":"additional","affiliation":[{"name":"1 ETH Zurich and Swiss Institute of Bioinformatics, Universit\u00e4tstrasse 6, 8092 Z\u00fcrich, Switzerland, 2Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), and UPF. Dr. Aiguader, 88, 08003 Barcelona, Spain, 3Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA, 4Stockholm Bioinformatics Center, Swedish eScience Research Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, 5European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Erik L. L.","family":"Sonnhammer","sequence":"additional","affiliation":[{"name":"1 ETH Zurich and Swiss Institute of Bioinformatics, Universit\u00e4tstrasse 6, 8092 Z\u00fcrich, Switzerland, 2Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), and UPF. Dr. Aiguader, 88, 08003 Barcelona, Spain, 3Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA, 4Stockholm Bioinformatics Center, Swedish eScience Research Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, 5European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"given":"Javier","family":"Herrero","sequence":"additional","affiliation":[{"name":"1 ETH Zurich and Swiss Institute of Bioinformatics, Universit\u00e4tstrasse 6, 8092 Z\u00fcrich, Switzerland, 2Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), and UPF. Dr. Aiguader, 88, 08003 Barcelona, Spain, 3Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA, 4Stockholm Bioinformatics Center, Swedish eScience Research Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, 5European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}]},{"name":"the Quest for Orthologs Consortium","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2012,2,12]]},"reference":[{"key":"2023012512222564900_B1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ddtec.2006.06.002","article-title":"Overview and comparison of ortholog databases","volume":"3","author":"Alexeyenko","year":"2006","journal-title":"Drug Discov Today"},{"key":"2023012512222564900_B2","doi-asserted-by":"crossref","first-page":"e1000262","DOI":"10.1371\/journal.pcbi.1000262","article-title":"Phylogenetic and functional assessment of orthologs inference projects and methods","volume":"5","author":"Altenhoff","year":"2009","journal-title":"PLoS Comput. 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