{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:50:47Z","timestamp":1776282647114,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications\u2014e.g. metabolic flux analysis\u2014require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known (13C, 15N, 18O, etc) to unusual (57Fe, 77Se, etc) isotopes. It also provides new features\u2014e.g. correction for the isotopic purity of the tracer\u2014to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community.<\/jats:p>\n               <jats:p>Availability: IsoCor is distributed under OpenSource license at http:\/\/metasys.insa-toulouse.fr\/software\/isocor\/<\/jats:p>\n               <jats:p>Contact: \u00a0jean-charles.portais@insa-toulouse.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts127","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T05:33:56Z","timestamp":1331789636000},"page":"1294-1296","source":"Crossref","is-referenced-by-count":265,"title":["IsoCor: correcting MS data in isotope labeling experiments"],"prefix":"10.1093","volume":"28","author":[{"given":"Pierre","family":"Millard","sequence":"first","affiliation":[{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"}]},{"given":"Fabien","family":"Letisse","sequence":"additional","affiliation":[{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"}]},{"given":"Serguei","family":"Sokol","sequence":"additional","affiliation":[{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"}]},{"given":"Jean-Charles","family":"Portais","sequence":"additional","affiliation":[{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"},{"name":"1 Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077 Toulouse, 2INRA, UMR792, Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, F-31400 Toulouse and 3CNRS, UMR5504, F-31400 Toulouse, France"}]}],"member":"286","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"2023012512304419900_B1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1137\/0916069","article-title":"A limited memory algorithm for bound constrained optimization","volume":"16","author":"Byrd","year":"1995","journal-title":"Siam. 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