{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:40:05Z","timestamp":1760708405867},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Recent genetic studies as well as recorded history point to massive growth in human population sizes during the recent past. To model and understand this growth accurately we introduce FTEC, an easy-to-use coalescent simulation program capable of simulating haplotype samples drawn from a population that has undergone faster than exponential growth. Samples drawn from a population that has undergone faster than exponential growth show an excess of very rare variation and more rapid LD decay when compared with samples drawn from a population that has maintained a constant size over time.<\/jats:p>\n               <jats:p>Availability: Source code for FTEC is freely available for download from the University of Michigan Center for Statistical Genetics Wiki at http:\/\/genome.sph.umich.edu\/wiki\/FTEC<\/jats:p>\n               <jats:p>Contact: \u00a0mreppell@umich.edu; szoellne@umich.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts135","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T15:58:31Z","timestamp":1332518311000},"page":"1282-1283","source":"Crossref","is-referenced-by-count":12,"title":["FTEC: a coalescent simulator for modeling faster than exponential growth"],"prefix":"10.1093","volume":"28","author":[{"given":"Mark","family":"Reppell","sequence":"first","affiliation":[{"name":"1 Department of Biostatistics and Center for Statistical Genetics and 2Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA"}]},{"given":"Michael","family":"Boehnke","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics and Center for Statistical Genetics and 2Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA"}]},{"given":"Sebastian","family":"Z\u00f6llner","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics and Center for Statistical Genetics and 2Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"1 Department of Biostatistics and Center for Statistical Genetics and 2Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA"}]}],"member":"286","published-online":{"date-parts":[[2012,3,21]]},"reference":[{"key":"2023012512304952500_B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"1000 Genomes Project Consortium.","year":"2010","journal-title":"Nature"},{"key":"2023012512304952500_B2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1534\/genetics.104.030171","article-title":"Maximum-likelihood estimation of demographic parameters using the frequency spectrum of unlinked single-nucleotide polymorphisms","volume":"168","author":"Adams","year":"2004","journal-title":"Genetics"},{"key":"2023012512304952500_B3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ncomms1130","article-title":"Deep resequencing reveals excess rare recent variants consistent with explosive population growth","volume":"1","author":"Coventry","year":"2010","journal-title":"Nat. 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