{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:46:41Z","timestamp":1769842001710,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1629,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The NanoString nCounter Platform is a new and promising technology for measuring nucleic acid abundances. It has several advantages over PCR-based techniques, including avoidance of amplification, direct sequence interrogation and digital detection for absolute quantification. These features minimize aspects of experimental error and hold promise for dealing with challenging experimental conditions such as archival formalin-fixed paraffin-embedded samples. However, systematic inter-sample technical artifacts caused by variability in sample preservation, bio-molecular extraction and platform fluctuations must be removed to ensure robust data.<\/jats:p>\n               <jats:p>Results: To facilitate this process and to address these issues for NanoString datasets, we have written a pre-processing package called NanoStringNorm in the R statistical language. Key features include an extensible environment for method comparison and new algorithm development, integrated gene and sample diagnostics, and facilitated downstream statistical analysis. The package is open-source, is available through the CRAN package repository, includes unit-tests to ensure numerical accuracy, and provides visual and numeric diagnostics.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/cran.r-project.org\/web\/packages\/NanoStringNorm<\/jats:p>\n               <jats:p>Contact: \u00a0paul.boutros@oicr.on.ca<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts188","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:25:22Z","timestamp":1334795122000},"page":"1546-1548","source":"Crossref","is-referenced-by-count":231,"title":["NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data"],"prefix":"10.1093","volume":"28","author":[{"given":"Daryl","family":"Waggott","sequence":"first","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]},{"given":"Kenneth","family":"Chu","sequence":"additional","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"},{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]},{"given":"Shaoming","family":"Yin","sequence":"additional","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"},{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]},{"given":"Bradly G.","family":"Wouters","sequence":"additional","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"},{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]},{"given":"Fei-Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"},{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]},{"given":"Paul C.","family":"Boutros","sequence":"additional","affiliation":[{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"},{"name":"1 Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada M5G 0A3, 2Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network and 3Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Canada, M5G 2M9"}]}],"member":"286","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"key":"2023012512312361800_B1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/1471-2105-12-479","article-title":"Normalization and differential expression analysis of NanoString nCounter data","volume":"12","author":"Brumbaugh","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2023012512312361800_B2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: a package for the generation of highly customizable Venn and Euler diagrams in R","volume":"12","author":"Chen","year":"2011","journal-title":"BMC 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