{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:00:34Z","timestamp":1696518034273},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Mixed model-based approaches to genome-wide association studies (GWAS) of binary traits in related individuals can account for non-genetic risk factors in an integrated manner. However, they are technically challenging. GLOGS (Genome-wide LOGistic mixed model\/Score test) addresses such challenges with efficient statistical procedures and a parallel implementation. GLOGS has high power relative to alternative approaches as risk covariate effects increase, and can complete a GWAS in minutes.<\/jats:p>\n               <jats:p>Availability: Source code and documentation are provided at http:\/\/www.bioinformatics.org\/~stanhope\/GLOGS.<\/jats:p>\n               <jats:p>Contact: \u00a0sstanhop@bsd.uchicago.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts190","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T01:24:27Z","timestamp":1334971467000},"page":"1553-1554","source":"Crossref","is-referenced-by-count":7,"title":["GLOGS: a fast and powerful method for GWAS of binary traits with risk covariates in related populations"],"prefix":"10.1093","volume":"28","author":[{"given":"Stephen A.","family":"Stanhope","sequence":"first","affiliation":[{"name":"Department of Human Genetics, University of Chicago, 920 E. 58th St., Chicago, IL 60637, USA"}]},{"given":"Mark","family":"Abney","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago, 920 E. 58th St., Chicago, IL 60637, USA"}]}],"member":"286","published-online":{"date-parts":[[2012,4,19]]},"reference":[{"key":"2023012512310830700_B1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/bioinformatics\/btp185","article-title":"A graphical algorithm for fast computation of identity coefficients and generalized kinship coefficients","volume":"25","author":"Abney","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012512310830700_B2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"2023012512310830700_B3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1086\/378208","article-title":"Novel case-control test in a founder population identifies P-selectin as an atopy susceptibility locus","volume":"73","author":"Bourgain","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"2023012512310830700_B4","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1093\/bioinformatics\/btm308","article-title":"TASSEL: software for association mapping of complex traits in diverse samples","volume":"23","author":"Bradbury","year":"2007","journal-title":"Bioinformatics"},{"key":"2023012512310830700_B5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/gepi.20614","article-title":"A comparison of strategies for analyzing dichotomous outcomes in genome-wide association studies with general pedigrees","volume":"35","author":"Chen","year":"2011","journal-title":"Genet. Epidemiol."},{"key":"2023012512310830700_B6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.548","article-title":"Variance component model to account for sample structure in genome-wide association studies","volume":"42","author":"Kang","year":"2010","journal-title":"Nat. Genet."},{"key":"2023012512310830700_B7","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/hmg\/7.9.1393","article-title":"Genome-wide search for asthma susceptibility loci in a founder population","volume":"7","author":"Ober","year":"1998","journal-title":"Human. Mol. Genet."},{"key":"2023012512310830700_B8","first-page":"1154","article-title":"A second-generation genomewide screen for asthma-susceptibility alleles in a founder population","volume":"67","author":"Ober","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"2023012512310830700_B9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg2813","article-title":"New approaches to population stratification in genome-wide association studies","volume":"11","author":"Price","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"2023012512310830700_B10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1086\/519497","article-title":"Case-control association testing with related individuals: a more powerful quasi-likelihood score test","volume":"81","author":"Thornton","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2023012512310830700_B11","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/bib\/bbp050","article-title":"Software engineering the mixed model for genome-wide association studies on large samples","volume":"10","author":"Zhang","year":"2009","journal-title":"Brief. Bioinform."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/11\/1553\/48867660\/bioinformatics_28_11_1553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/11\/1553\/48867660\/bioinformatics_28_11_1553.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:59:17Z","timestamp":1674662357000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/28\/11\/1553\/267439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,19]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bts190","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2012,6,1]]},"published":{"date-parts":[[2012,4,19]]}}}