{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T05:20:12Z","timestamp":1674710412897},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Most proteins lack experimentally validated functions. To address this problem, we implemented the Evolutionary Trace Annotation (ETA) method in the Cytoscape network visualization environment. The result is the ETAscape plugin, which builds a structural genomics network based on local structural and evolutionary similarities among proteins and then globally diffuses known annotations across the resulting network. The plugin displays these novel functional annotations, their confidence, the molecular basis for individual matches and the set of matches that lead to a prediction.<\/jats:p>\n               <jats:p>Availability: The ETA Network Plugin is available publicly for download at http:\/\/mammoth.bcm.tmc.edu\/networks\/.<\/jats:p>\n               <jats:p>Contact: \u00a0lichtarge@bcm.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts331","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T02:28:09Z","timestamp":1339468089000},"page":"2186-2188","source":"Crossref","is-referenced-by-count":6,"title":["ETAscape: analyzing protein networks to predict enzymatic function and substrates in Cytoscape"],"prefix":"10.1093","volume":"28","author":[{"given":"Benjamin J.","family":"Bachman","sequence":"first","affiliation":[{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"},{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"},{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"}]},{"given":"Eric","family":"Venner","sequence":"additional","affiliation":[{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"},{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"}]},{"given":"Rhonald C.","family":"Lua","sequence":"additional","affiliation":[{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"}]},{"given":"Serkan","family":"Erdin","sequence":"additional","affiliation":[{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"}]},{"given":"Olivier","family":"Lichtarge","sequence":"additional","affiliation":[{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"},{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"},{"name":"1 Departments of Molecular and Human Genetics, 2Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 and 3W. M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX 77005, USA"}]}],"member":"286","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"2023012512530907100_B1","doi-asserted-by":"crossref","first-page":"e1002244","DOI":"10.1371\/journal.pgen.1002244","article-title":"Separation of recombination and SOS response in escherichia coli RecA suggests LexA interaction sites","volume":"7","author":"Adikesavan","year":"2011","journal-title":"PLoS Genet."},{"key":"2023012512530907100_B2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023012512530907100_B3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.sbi.2011.02.001","article-title":"Protein function prediction: towards integration of similarity metrics","volume":"21","author":"Erdin","year":"2011","journal-title":"Curr. Opin. 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