{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:15:57Z","timestamp":1776150957836,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.<\/jats:p>\n               <jats:p>Availability: The plug-in and its user guide can be downloaded freely from: http:\/\/www.linkgroup.hu\/modules.php.<\/jats:p>\n               <jats:p>Contact: \u00a0csermely.peter@med.semmelweis-univ.hu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts352","type":"journal-article","created":{"date-parts":[[2012,6,23]],"date-time":"2012-06-23T08:09:48Z","timestamp":1340438988000},"page":"2202-2204","source":"Crossref","is-referenced-by-count":98,"title":["ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality"],"prefix":"10.1093","volume":"28","author":[{"given":"M\u00e1t\u00e9","family":"Szalay-Bek\u0151","sequence":"first","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]},{"given":"Robin","family":"Palotai","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]},{"given":"Bal\u00e1zs","family":"Szappanos","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]},{"given":"Istv\u00e1n A.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]},{"given":"Bal\u00e1zs","family":"Papp","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]},{"given":"P\u00e9ter","family":"Csermely","sequence":"additional","affiliation":[{"name":"1 Department of Medical Chemistry, Semmelweis University, Budapest 1444, 2Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged 6726, 3Department of Physics, Lor\u00e1nd E\u00f6tv\u00f6s University and 4Institute for Solid State Physics and Optics, Wigner Research Centre, Hungarian Academy of Sciences, Budapest 1525, Hungary"}]}],"member":"286","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"2023012512560212600_B1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/bioinformatics\/btl039","article-title":"CFinder: Locating cliques and overlapping modules in biological networks","volume":"22","author":"Adamcsek","year":"2006","journal-title":"Bioinformatics"},{"key":"2023012512560212600_B2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature09182","article-title":"Link communities reveal multiscale complexity in networks","volume":"466","author":"Ahn","year":"2010","journal-title":"Nature"},{"key":"2023012512560212600_B3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"2023012512560212600_B4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.physrep.2009.11.002","article-title":"Community detection in graphs","volume":"486","author":"Fortunato","year":"2010","journal-title":"Phys. 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