{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:05:56Z","timestamp":1745561156365},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1490,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The analysis of expression quantitative trait locus (eQTL) data is a challenging scientific endeavor, involving the processing of very large, heterogeneous and complex data. Typical eQTL analyses involve three types of data: sequence-based data reflecting the genotypic variations, gene expression data and meta-data describing the phenotype. Based on these, certain genotypes can be connected with specific phenotypic outcomes to infer causal associations of genetic variation, expression and disease.<\/jats:p>\n               <jats:p>To this end, statistical methods are used to find significant associations between single nucleotide polymorphisms (SNPs) or pairs of SNPs and gene expression. A major challenge lies in summarizing the large amount of data as well as statistical results and to generate informative, interactive visualizations.<\/jats:p>\n               <jats:p>Results: We present Reveal, our visual analytics approach to this challenge. We introduce a graph-based visualization of associations between SNPs and gene expression and a detailed genotype view relating summarized patient cohort genotypes with data from individual patients and statistical analyses.<\/jats:p>\n               <jats:p>Availability: Reveal is included in Mayday, our framework for visual exploration and analysis. It is available at http:\/\/it.inf.uni-tuebingen.de\/software\/reveal\/.<\/jats:p>\n               <jats:p>Contact: \u00a0guenter.jaeger@uni-tuebingen.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts382","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T20:35:22Z","timestamp":1347050122000},"page":"i542-i548","source":"Crossref","is-referenced-by-count":1,"title":["R<scp>eveal<\/scp>\u2014visual eQTL analytics"],"prefix":"10.1093","volume":"28","author":[{"given":"G\u00fcnter","family":"J\u00e4ger","sequence":"first","affiliation":[{"name":"1 Integrative Transcriptomics, Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"}]},{"given":"Florian","family":"Battke","sequence":"additional","affiliation":[{"name":"1 Integrative Transcriptomics, Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"}]},{"given":"Kay","family":"Nieselt","sequence":"additional","affiliation":[{"name":"1 Integrative Transcriptomics, Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany"}]}],"member":"286","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"2023012513073086000_B1","volume-title":"Genespring","author":"Agilent","year":"2012"},{"key":"2023012513073086000_B2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2105-11-121","article-title":"Mayday\u2014integrative analytics for expression data","volume":"11","author":"Battke","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023012513073086000_B3","doi-asserted-by":"crossref","DOI":"10.1109\/BioVis.2011.6094052","article-title":"GenAMap: visualization strategies for structured association mapping","volume-title":"Proceeding BioVis Symposium","author":"Curtis","year":"2011"},{"key":"2023012513073086000_B4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"Dubois","year":"2010","journal-title":"Nat. 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