{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:42:31Z","timestamp":1792856551555,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Residue\u2013residue contact prediction is important for protein structure prediction and other applications. However, the accuracy of current contact predictors often barely exceeds 20% on long-range contacts, falling short of the level required for ab initio structure prediction.<\/jats:p>\n               <jats:p>Results: Here, we develop a novel machine learning approach for contact map prediction using three steps of increasing resolution. First, we use 2D recursive neural networks to predict coarse contacts and orientations between secondary structure elements. Second, we use an energy-based method to align secondary structure elements and predict contact probabilities between residues in contacting alpha-helices or strands. Third, we use a deep neural network architecture to organize and progressively refine the prediction of contacts, integrating information over both space and time. We train the architecture on a large set of non-redundant proteins and test it on a large set of non-homologous domains, as well as on the set of protein domains used for contact prediction in the two most recent CASP8 and CASP9 experiments. For long-range contacts, the accuracy of the new CMAPpro predictor is close to 30%, a significant increase over existing approaches.<\/jats:p>\n               <jats:p>Availability: CMAPpro is available as part of the SCRATCH suite at http:\/\/scratch.proteomics.ics.uci.edu\/.<\/jats:p>\n               <jats:p>Contact: \u00a0pfbaldi@uci.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts475","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T06:55:55Z","timestamp":1343717755000},"page":"2449-2457","source":"Crossref","is-referenced-by-count":230,"title":["Deep architectures for protein contact map prediction"],"prefix":"10.1093","volume":"28","author":[{"given":"Pietro","family":"Di Lena","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"},{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Nagata","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"},{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Baldi","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"},{"name":"1 Department of Computer Science, University of California, Irvine, CA 92697, USA and 2Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,30]]},"reference":[{"key":"2023012513061835700_bts475-B1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. 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