{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:23:41Z","timestamp":1772151821442,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1524,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Identification of metabolites using high-resolution multi-stage mass spectrometry (MSn) data is a significant challenge demanding access to all sorts of computational infrastructures. MetiTree is a user-friendly, web application dedicated to organize, process, share, visualize and compare MSn data. It integrates several features to export and visualize complex MSn data, facilitating the exploration and interpretation of metabolomics experiments. A dedicated spectral tree viewer allows the simultaneous presentation of three related types of MSn data, namely, the spectral data, the fragmentation tree and the fragmentation reactions. MetiTree stores the data in an internal database to enable searching for similar fragmentation trees and matching against other MSn data. As such MetiTree contains much functionality that will make the difficult task of identifying unknown metabolites much easier.<\/jats:p>\n               <jats:p>Availability: MetiTree is accessible at http:\/\/www.MetiTree.nl. The source code is available at https:\/\/github.com\/NetherlandsMetabolomicsCentre\/metitree\/wiki.<\/jats:p>\n               <jats:p>Contact: \u00a0m.rojas@lacdr.leidenuniv.nl or t.reijmers@lacdr.leidenuniv.nl<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts486","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T04:48:10Z","timestamp":1343796490000},"page":"2707-2709","source":"Crossref","is-referenced-by-count":23,"title":["MetiTree: a web application to organize and process high-resolution multi-stage mass spectrometry metabolomics data"],"prefix":"10.1093","volume":"28","author":[{"given":"Miguel","family":"Rojas-Chert\u00f3","sequence":"first","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"van Vliet","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio E.","family":"Peironcely","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"van Doorn","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Kooyman","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"te Beek","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"van Driel","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hankemeier","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Reijmers","sequence":"additional","affiliation":[{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. Box 360, NL-3700 AJ Zeist, The Netherlands"},{"name":"1 Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC Leiden and 2Division of Analytical Biosciences, Leiden\/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden and 3Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA Nijmegen and 4TNO Research Group Quality and Safety, P.O. 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