{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:59:25Z","timestamp":1773165565723,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Ontologies are used in the annotation and analysis of biological data. As knowledge accumulates, ontologies and annotation undergo constant modifications to reflect this new knowledge. These modifications may influence the results of statistical applications such as functional enrichment analyses that describe experimental data in terms of ontological groupings. Here, we investigate to what degree modifications of the Gene Ontology (GO) impact these statistical analyses for both experimental and simulated data. The analysis is based on new measures for the stability of result sets and considers different ontology and annotation changes.<\/jats:p>\n               <jats:p>Results: Our results show that past changes in the GO are non-uniformly distributed over different branches of the ontology. Considering the semantic relatedness of significant categories in analysis results allows a more realistic stability assessment for functional enrichment studies. We observe that the results of term-enrichment analyses tend to be surprisingly stable despite changes in ontology and annotation.<\/jats:p>\n               <jats:p>Contact: \u00a0gross@informatik.uni-leipzig.de<\/jats:p>\n               <jats:p>Supplementary information: Supplementary Data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts498","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T01:09:09Z","timestamp":1346980149000},"page":"2671-2677","source":"Crossref","is-referenced-by-count":28,"title":["Impact of ontology evolution on functional analyses"],"prefix":"10.1093","volume":"28","author":[{"given":"Anika","family":"Gro\u00df","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, University of Leipzig, P.O.Box 100920, 04009 Leipzig and 2Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany"}]},{"given":"Michael","family":"Hartung","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Leipzig, P.O.Box 100920, 04009 Leipzig and 2Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany"}]},{"given":"Kay","family":"Pr\u00fcfer","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Leipzig, P.O.Box 100920, 04009 Leipzig and 2Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany"}]},{"given":"Janet","family":"Kelso","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Leipzig, P.O.Box 100920, 04009 Leipzig and 2Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany"}]},{"given":"Erhard","family":"Rahm","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Leipzig, P.O.Box 100920, 04009 Leipzig and 2Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany"}]}],"member":"286","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"2023012513134920500_bts498-B1","first-page":"288","volume":"25","author":"Carbon","year":"2009","journal-title":"Amigo: online access to ontology and annotation data. 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