{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:22:11Z","timestamp":1768004531755,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: In modern sequencing studies, one can improve the confidence of genotype calls by phasing haplotypes using information from an external reference panel of fully typed unrelated individuals. However, the computational demands are so high that they prohibit researchers with limited computational resources from haplotyping large-scale sequence data.<\/jats:p>\n               <jats:p>Results: Our graphics processing unit based software delivers haplotyping and imputation accuracies comparable to competing programs at a fraction of the computational cost and peak memory demand.<\/jats:p>\n               <jats:p>Availability: \u00a0Mendel-GPU, our OpenCL software, runs on Linux platforms and is portable across AMD and nVidia GPUs. Users can download both code and documentation at http:\/\/code.google.com\/p\/mendel-gpu\/.<\/jats:p>\n               <jats:p>Contact: \u00a0gary.k.chen@usc.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts536","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T01:09:09Z","timestamp":1346980149000},"page":"2979-2980","source":"Crossref","is-referenced-by-count":10,"title":["Mendel-GPU: haplotyping and genotype imputation on graphics processing units"],"prefix":"10.1093","volume":"28","author":[{"given":"Gary K.","family":"Chen","sequence":"first","affiliation":[{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"}]},{"given":"Alex H.","family":"Stram","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"}]},{"given":"Eric M.","family":"Sobel","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"}]},{"given":"Kenneth","family":"Lange","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"},{"name":"1 Department of Preventive Medicine, 2Zilkha Neurogenetic Institute, USC, Los Angeles, CA 90089, 3Department of Human Genetics, 4Department of Biomathematics, UCLA, Los Angeles, CA 90095, USA"}]}],"member":"286","published-online":{"date-parts":[[2012,9,5]]},"reference":[{"key":"2023012513220694100_bts536-B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"key":"2023012513220694100_bts536-B2","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/bioinformatics\/btn236","article-title":"Penalized estimation of haplotype frequencies","volume":"24","author":"Ayers","year":"2008","journal-title":"Bioinformatics"},{"key":"2023012513220694100_bts536-B3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering","volume":"81","author":"Browning","year":"2007","journal-title":"Am. 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