{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:24:06Z","timestamp":1784399046930,"version":"3.55.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We propose a parametric model, HiCNorm, to remove systematic biases in the raw Hi-C contact maps, resulting in a simple, fast, yet accurate normalization procedure. Compared with the existing Hi-C normalization method developed by Yaffe and Tanay, HiCNorm has fewer parameters, runs &amp;gt;1000 times faster and achieves higher reproducibility.<\/jats:p>\n               <jats:p>Availability: Freely available on the web at: http:\/\/www.people.fas.harvard.edu\/\u223cjunliu\/HiCNorm\/.<\/jats:p>\n               <jats:p>Contact: \u00a0jliu@stat.harvard.edu<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts570","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:38:58Z","timestamp":1349051938000},"page":"3131-3133","source":"Crossref","is-referenced-by-count":238,"title":["HiCNorm: removing biases in Hi-C data via Poisson regression"],"prefix":"10.1093","volume":"28","author":[{"given":"Ming","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddarth","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun S.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,27]]},"reference":[{"key":"2023062411485743600_bts570-B1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"IEEE Trans. Automat. Control"},{"key":"2023062411485743600_bts570-B2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science"},{"key":"2023062411485743600_bts570-B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-3242-6","volume-title":"Generalized Linear Models","author":"McCullagh","year":"1989"},{"key":"2023062411485743600_bts570-B4","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1242\/jcs.051631","article-title":"Integrating one-dimensional and three-dimensional maps of genomes","volume":"123","author":"Naumov","year":"2010","journal-title":"J. Cell Sci."},{"key":"2023062411485743600_bts570-B5","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ng.947","article-title":"Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture","volume":"43","author":"Yaffe","year":"2011","journal-title":"Nat. Genet."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/23\/3131\/50694926\/bioinformatics_28_23_3131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/28\/23\/3131\/50694926\/bioinformatics_28_23_3131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T11:49:17Z","timestamp":1687607357000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/28\/23\/3131\/192582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,27]]},"references-count":5,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bts570","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,12]]},"published":{"date-parts":[[2012,9,27]]}}}