{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:26:18Z","timestamp":1784175978077,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Effective access to the vast biomedical knowledge present in the scientific literature is challenging. Semantic relations are increasingly used in knowledge management applications supporting biomedical research to help address this challenge. We describe SemMedDB, a repository of semantic predications (subject\u2013predicate\u2013object triples) extracted from the entire set of PubMed citations. We propose the repository as a knowledge resource that can assist in hypothesis generation and literature-based discovery in biomedicine as well as in clinical decision-making support.<\/jats:p>\n               <jats:p>Availability and implementation: The SemMedDB repository is available as a MySQL database for non-commercial use at http:\/\/skr3.nlm.nih.gov\/SemMedDB. An UMLS Metathesaurus license is required.<\/jats:p>\n               <jats:p>Contact: \u00a0kilicogluh@mail.nih.gov<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts591","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:42:28Z","timestamp":1349743348000},"page":"3158-3160","source":"Crossref","is-referenced-by-count":315,"title":["SemMedDB: a PubMed-scale repository of biomedical semantic predications"],"prefix":"10.1093","volume":"28","author":[{"given":"Halil","family":"Kilicoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwook","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Fiszman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Rosemblat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Rindflesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"2023062412005073600_bts591-B1","first-page":"209","article-title":"Extracting semantic predications from Medline citations for pharmacogenomics","volume-title":"Pacific Symposium on Biocomputing","author":"Ahlers","year":"2007"},{"key":"2023062412005073600_bts591-B2","first-page":"28","article-title":"Scaling up biomedical event extraction to the entire PubMed","volume-title":"Proceedings of the Workshop on Biomedical Natural Language Processing (BioNLP\u201910)","author":"Bj\u00f6rne","year":"2010"},{"key":"2023062412005073600_bts591-B3","first-page":"82","article-title":"PubMed-scale event extraction for post-translational modifications, epigenetics and protein structural relations","volume-title":"Proceedings of the Workshop on Biomedical Natural Language Processing (BioNLP\u201912)","author":"Bj\u00f6rne","year":"2012"},{"key":"2023062412005073600_bts591-B4","doi-asserted-by":"crossref","first-page":"D267","DOI":"10.1093\/nar\/gkh061","article-title":"The unified medical language system (UMLS): integrating biomedical terminology","volume":"32","author":"Bodenreider","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023062412005073600_bts591-B5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5210\/disco.v5i0.3090","article-title":"EpiphaNet: an interactive tool to support biomedical discoveries","volume":"5","author":"Cohen","year":"2010","journal-title":"J. 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