{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:13:23Z","timestamp":1768562003126,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1433,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: In higher eukaryotes, the identification of translation initiation sites (TISs) has been focused on finding these signals in cDNA or mRNA sequences. Using Arabidopsis thaliana (A.t.) information, we developed a prediction tool for signals within genomic sequences of plants that correspond to TISs. Our tool requires only genome sequence, not expressed sequences. Its sensitivity\/specificity is for A.t. (90.75%\/92.2%), for Vitis vinifera (66.8%\/94.4%) and for Populus trichocarpa (81.6%\/94.4%), which suggests that our tool can be used in annotation of different plant genomes. We provide a list of features used in our model. Further study of these features may improve our understanding of mechanisms of the translation initiation.<\/jats:p><jats:p>Availability and implementation: Our tool is implemented as an artificial neural network. It is available as a web-based tool and, together with the source code, the list of features, and data used for model development, is accessible at http:\/\/cbrc.kaust.edu.sa\/dts.<\/jats:p><jats:p>Contact: \u00a0vladimir.bajic@kaust.edu.sa<\/jats:p><jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts638","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T04:41:41Z","timestamp":1351658501000},"page":"117-118","source":"Crossref","is-referenced-by-count":21,"title":["Dragon TIS Spotter: an Arabidopsis-derived predictor of translation initiation sites in plants"],"prefix":"10.1093","volume":"29","author":[{"given":"Arturo","family":"Magana-Mora","sequence":"first","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Ashoor","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris R.","family":"Jankovic","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Kamau","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Awara","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.C.","family":"Archer","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir B.","family":"Bajic","sequence":"additional","affiliation":[{"name":"1 King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal 23955-6900, Saudi Arabia and 2Biomedical formatics Research Center, MCRF, Marshfield Clinic, Marshfield, WI 54449, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"2023020303200535500_bts638-B1","first-page":"137","article-title":"Computational approaches to gene prediction","volume":"44","author":"Do","year":"2006","journal-title":"J. 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