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A specially developed XML language, FluxML, highly efficient data structures and simulation algorithms achieve a maximum of performance and effectiveness. Support of multicore CPUs, as well as compute clusters, enables scalable investigations. 13CFLUX2 outperforms existing tools in terms of universality, flexibility and built-in features. Therewith, 13CFLUX2 paves the way for next-generation high-resolution 13C-MFA applications on the large scale.<\/jats:p><jats:p>Availability and implementation: 13CFLUX2 is implemented in C++ (ISO\/IEC 14882 standard) with Java and Python add-ons to run under Linux\/Unix. A demo version and binaries are available at www.13cflux.net.<\/jats:p><jats:p>Contact: \u00a0info@13cflux.net or k.noeh@fz-juelich.de<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts646","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T04:41:41Z","timestamp":1351658501000},"page":"143-145","source":"Crossref","is-referenced-by-count":180,"title":["13CFLUX2\u2014high-performance software suite for 13C-metabolic flux analysis"],"prefix":"10.1093","volume":"29","author":[{"given":"Michael","family":"Weitzel","sequence":"first","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"N\u00f6h","sequence":"additional","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Dalman","sequence":"additional","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Niedenf\u00fchr","sequence":"additional","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Stute","sequence":"additional","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wiechert","sequence":"additional","affiliation":[{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"},{"name":"1 Institute of Bio- and Geosciences, IBG-1: Biotechnology and 2JARA High Performance Computing, Forschungszentrum J\u00fclich GmbH, 52428 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"2023020303203345900_bts646-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ymben.2006.09.001","article-title":"Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions","volume":"9","author":"Antoniewicz","year":"2007","journal-title":"Metab. 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