{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:32:55Z","timestamp":1778830375814,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The systematic and unbiased charting of protein\u2013protein interaction (PPI) networks relevant to health or diseases has become an important and burgeoning challenge in systems biology. Further, current reports have supported that good correlation exists between the topological properties and biological function of protein nodes in networks. Coronary artery disease (CAD, also called coronary heart disease) is the most common type of heart disease worldwide. Traditional approaches of studying individual gene or protein have shown their weakness in such complex disease. Here, we provide NetCAD, a web-based tool for systematic investigation of CAD-specific proteins in human PPI network. The features of NetCAD includes the following: proposing a novel method combining biological principles and graph theory, quantified topological analysis tools, build-in PPI information database consolidated from major public databases, creating CAD-associated subnetwork and visualizing network graph with good visual effects. NetCAD may provide important biological information for uncovering the molecular mechanisms and potential targets for therapies of CAD, which could not be found merely through molecular biology methods.<\/jats:p>\n               <jats:p>Availability and implementation: NetCAD is freely available at: http:\/\/www.herbbol.org\/netcad\/.<\/jats:p>\n               <jats:p>Contact: \u00a0zhliu@implad.ac.cn or zhliu.liulab@foxmail.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts666","type":"journal-article","created":{"date-parts":[[2012,11,18]],"date-time":"2012-11-18T02:50:02Z","timestamp":1353207002000},"page":"279-280","source":"Crossref","is-referenced-by-count":20,"title":["NetCAD: a network analysis tool for coronary artery disease-associated PPI network"],"prefix":"10.1093","volume":"29","author":[{"given":"Guomin","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,17]]},"reference":[{"key":"2023012810180609100_bts666-B1","doi-asserted-by":"crossref","first-page":"A10","DOI":"10.1016\/j.jacc.2006.06.046","article-title":"Genetic approaches to coronary heart disease","volume":"48","author":"Cohen","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"2023012810180609100_bts666-B2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1101\/gr.071852.107","article-title":"Protein networks in disease","volume":"18","author":"Ideker","year":"2008","journal-title":"Genome Res."},{"key":"2023012810180609100_bts666-B3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1541-0420.2010.01519.x","article-title":"Network-based auto-probit modeling for protein function prediction","volume":"67","author":"Jiang","year":"2011","journal-title":"Biometrics"},{"key":"2023012810180609100_bts666-B4","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gkq1106","article-title":"CADgene: a comprehensive database for coronary artery disease genes","volume":"39","author":"Liu","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023012810180609100_bts666-B5","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1159\/000258197","article-title":"MiR-106b and MiR-15b modulate apoptosis and angiogenesis in myocardial infarction","volume":"29","author":"Liu","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"2023012810180609100_bts666-B6","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1093\/bioinformatics\/btq430","article-title":"Cytoscape Web: an interactive web-based network browser","volume":"26","author":"Lopes","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012810180609100_bts666-B7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4137\/CIN.S3899","article-title":"Protein-protein interaction reveals synergistic discrimination of cancer phenotype","volume":"9","author":"Xiong","year":"2010","journal-title":"Cancer Inform."},{"key":"2023012810180609100_bts666-B8","doi-asserted-by":"crossref","first-page":"e42076","DOI":"10.1371\/journal.pone.0042076","article-title":"Ischemia\/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1\/2 pathway","volume":"7","author":"Yang","year":"2012","journal-title":"PloS ONE"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/29\/2\/279\/48891169\/bioinformatics_29_2_279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/29\/2\/279\/48891169\/bioinformatics_29_2_279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T10:18:28Z","timestamp":1674901108000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/29\/2\/279\/202073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,17]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bts666","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,1,15]]},"published":{"date-parts":[[2012,11,17]]}}}