{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:54:19Z","timestamp":1777564459754,"version":"3.51.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We introduce a novel implementation in ANSI C of the MINE family of algorithms for computing maximal information-based measures of dependence between two variables in large datasets, with the aim of a low memory footprint and ease of integration within bioinformatics pipelines. We provide the libraries minerva (with the R interface) and minepy for Python, MATLAB, Octave and C++. The C solution reduces the large memory requirement of the original Java implementation, has good upscaling properties and offers a native parallelization for the R interface. Low memory requirements are demonstrated on the MINE benchmarks as well as on large ( = 1340) microarray and Illumina GAII RNA-seq transcriptomics datasets.<\/jats:p>\n               <jats:p>Availability and implementation: Source code and binaries are freely available for download under GPL3 licence at http:\/\/minepy.sourceforge.net for minepy and through the CRAN repository http:\/\/cran.r-project.org for the R package minerva. All software is multiplatform (MS Windows, Linux and OSX).<\/jats:p>\n               <jats:p>Contact: \u00a0furlan@fbk.eu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts707","type":"journal-article","created":{"date-parts":[[2012,12,16]],"date-time":"2012-12-16T01:19:48Z","timestamp":1355620788000},"page":"407-408","source":"Crossref","is-referenced-by-count":197,"title":["minerva and minepy: a C engine for the MINE suite and its R, Python and MATLAB wrappers"],"prefix":"10.1093","volume":"29","author":[{"given":"Davide","family":"Albanese","sequence":"first","affiliation":[{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Filosi","sequence":"additional","affiliation":[{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), Italy"},{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), Italy"},{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Visintainer","sequence":"additional","affiliation":[{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), Italy"},{"name":"1 Fondazione Bruno Kessler, via Sommarive 18, I-38123 Povo (Trento), Italy, 2CIBIO, University of Trento, via delle Regole 101, I-38123 Mattarello (Trento), Italy, 3The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA and 4DISI, University of Trento, Via Sommarive 5, I-38123 Povo (Trento), 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