{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T05:22:54Z","timestamp":1674969774617},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The computational evaluation of candidate genes for hereditary disorders is a non-trivial task. Several excellent methods for disease-gene prediction have been developed in the past 2 decades, exploiting widely differing data sources to infer disease-relevant functional relationships between candidate genes and disorders. We have shown recently that spatially mapped, i.e. 3D, gene expression data from the mouse brain can be successfully used to prioritize candidate genes for human Mendelian disorders of the central nervous system.<\/jats:p>\n               <jats:p>Results: We improved our previous work 2-fold: (i) we demonstrate that condition-independent transcription factor binding affinities of the candidate genes\u2019 promoters are relevant for disease-gene prediction and can be integrated with our previous approach to significantly enhance its predictive power; and (ii) we define a novel similarity measure\u2014termed Relative Intensity Overlap\u2014for both 3D gene expression patterns and binding affinity profiles that better exploits their disease-relevant information content. Finally, we present novel disease-gene predictions for eight loci associated with different syndromes of unknown molecular basis that are characterized by mental retardation.<\/jats:p>\n               <jats:p>Contact: \u00a0r.piro@dkfz.de or rmpiro@gmail.com<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts720","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T03:12:57Z","timestamp":1356405177000},"page":"468-475","source":"Crossref","is-referenced-by-count":4,"title":["Disease-gene discovery by integration of 3D gene expression and transcription factor binding affinities"],"prefix":"10.1093","volume":"29","author":[{"given":"Rosario M.","family":"Piro","sequence":"first","affiliation":[{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"},{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Molineris","sequence":"additional","affiliation":[{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"},{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Di Cunto","sequence":"additional","affiliation":[{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"},{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), 2Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Im 69120 Heidelberg, Germany, 3Molecular Biotechnology Center and 4Department of Molecular Biotechnologies and Health Sciences, University of Torino, 0126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[{"name":"1 Department of Theoretical Bioinformatics, German Cancer Research Center 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