{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:58:07Z","timestamp":1769605087156,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1355,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Advances in sequencing technology have greatly reduced the costs incurred in collecting raw sequencing data. Academic laboratories and researchers therefore now have access to very large datasets of genomic alterations but limited time and computational resources to analyse their potential biological importance. Here, we provide a web-based application, Cancer-Related Analysis of Variants Toolkit, designed with an easy-to-use interface to facilitate the high-throughput assessment and prioritization of genes and missense alterations important for cancer tumorigenesis. Cancer-Related Analysis of Variants Toolkit provides predictive scores for germline variants, somatic mutations and relative gene importance, as well as annotations from published literature and databases. Results are emailed to users as MS Excel spreadsheets and\/or tab-separated text files.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.cravat.us\/<\/jats:p>\n               <jats:p>Contact: \u00a0karchin@jhu.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt017","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T07:02:12Z","timestamp":1358406132000},"page":"647-648","source":"Crossref","is-referenced-by-count":123,"title":["CRAVAT: cancer-related analysis of variants toolkit"],"prefix":"10.1093","volume":"29","author":[{"given":"Christopher","family":"Douville","sequence":"first","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Carter","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Kim","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noushin","family":"Niknafs","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Diekhans","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Stenson","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ryan","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Karchin","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA, 2In Silico Solutions, Fairfax, VA, USA, 3Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95076, USA and 4Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"2023051607330958000_btt017-B1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1162\/neco.1997.9.7.1545","article-title":"Shape quantization","volume":"9","author":"Amit","year":"1997","journal-title":"Neural. 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