{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T06:05:50Z","timestamp":1749103550690},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Many drug or single nucleotide polymorphism (SNP)-related resources and tools have been developed, but connecting and integrating them is still a challenge. Here, we describe a user-friendly web-based software package, named Drug-SNPing, which provides a platform for the integration of drug information (DrugBank and PharmGKB), protein\u2013protein interactions (STRING), tagSNP selection (HapMap) and genotyping information (dbSNP, REBASE and SNP500Cancer). DrugBank-based inputs include the following: (i) common name of the drug, (ii) synonym or drug brand name, (iii) gene name (HUGO) and (iv) keywords. PharmGKB-based inputs include the following: (i) gene name (HUGO), (ii) drug name and (iii) disease-related keywords. The output provides drug-related information, metabolizing enzymes and drug targets, as well as protein\u2013protein interaction data. Importantly, tagSNPs of the selected genes are retrieved for genotyping analyses. All drug-based and protein\u2013protein interaction-based SNP genotyping information are provided with PCR-RFLP (PCR-restriction enzyme length polymorphism) and TaqMan probes. Thus, users can enter any drug keywords\/brand names to obtain immediate information that is highly relevant to genotyping for pharmacogenomics research.<\/jats:p>\n               <jats:p>Availability and implementation: Drug-SNPing and its user manual are freely available at http:\/\/bio.kuas.edu.tw\/drug-snping\/.<\/jats:p>\n               <jats:p>Contact: \u00a0chuang@isu.edu.tw; yuhuei.cheng@gmail.com; changhw@kmu.edu.tw<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt037","type":"journal-article","created":{"date-parts":[[2013,2,16]],"date-time":"2013-02-16T05:36:01Z","timestamp":1360992961000},"page":"758-764","source":"Crossref","is-referenced-by-count":16,"title":["Drug-SNPing: an integrated drug-based, protein interaction-based tagSNP-based pharmacogenomics platform for SNP genotyping"],"prefix":"10.1093","volume":"29","author":[{"given":"Cheng-Hong","family":"Yang","sequence":"first","affiliation":[{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Huei","family":"Cheng","sequence":"additional","affiliation":[{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yeh","family":"Chuang","sequence":"additional","affiliation":[{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"1 Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, 2Department of Digital Content Design and Management, Toko University, Chiayi, 3Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, 4Department of Biomedical Science and Environmental Biology, 5Graduate Institute of Natural Products and 6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"2023012810251380600_btt037-B1","doi-asserted-by":"crossref","first-page":"D195","DOI":"10.1093\/nar\/gkn618","article-title":"SuperSite: dictionary of metabolite and drug binding sites in proteins","volume":"37","author":"Andre Bauer","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B2","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/1471-2164-10-S3-S13","article-title":"MapNext: a software tool for spliced and unspliced alignments and SNP detection of short sequence reads","volume":"10","author":"Bao","year":"2009","journal-title":"BMC Genomics"},{"key":"2023012810251380600_btt037-B3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00335-008-9149-2","article-title":"SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs","volume":"19","author":"Beckstead","year":"2008","journal-title":"Mamm. Genome"},{"key":"2023012810251380600_btt037-B4","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2105-6-S4-S6","article-title":"MicroGen: a MIAME compliant web system for microarray experiment information and workflow management","volume":"6","author":"Burgarella","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"2023012810251380600_btt037-B5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/toxsci\/kfj097","article-title":"dbZach: a MIAME-compliant toxicogenomic supportive relational database","volume":"90","author":"Burgoon","year":"2006","journal-title":"Toxicol. Sci."},{"key":"2023012810251380600_btt037-B6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2164-7-30","article-title":"SNP-RFLPing: restriction enzyme mining for SNPs in genomes","volume":"7","author":"Chang","year":"2006","journal-title":"BMC Genomics"},{"key":"2023012810251380600_btt037-B7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/omi.2008.0058","article-title":"Seq-SNPing: multiple-alignment tool for SNP discovery, SNP ID identification, and RFLP genotyping","volume":"13","author":"Chang","year":"2009","journal-title":"OMICS"},{"key":"2023012810251380600_btt037-B8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2144\/000113092","article-title":"Prim-SNPing: a primer designer for cost-effective SNP genotyping","volume":"46","author":"Chang","year":"2009","journal-title":"Biotechniques"},{"key":"2023012810251380600_btt037-B9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2105-11-173","article-title":"SNP-RFLPing 2: an updated and integrated PCR-RFLP database tool for SNP genotyping","volume":"11","author":"Chang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023012810251380600_btt037-B10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2174\/138920012802138679","article-title":"The importance of integrating SNP and cheminformatics resources to pharmacogenomics","volume":"13","author":"Chang","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"2023012810251380600_btt037-B11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.tpj.6500167","article-title":"Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput","volume":"3","author":"Chen","year":"2003","journal-title":"Pharmacogenomics J."},{"key":"2023012810251380600_btt037-B12","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1093\/bioinformatics\/bti683","article-title":"ChemDB: a public database of small molecules and related chemoinformatics resources","volume":"21","author":"Chen","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B13","first-page":"2001","article-title":"Restriction enzyme mining for SNPs in genomes","volume":"28","author":"Chuang","year":"2008","journal-title":"Anticancer Res."},{"key":"2023012810251380600_btt037-B14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrg2751","article-title":"Genome-wide association studies in pharmacogenomics","volume":"11","author":"Daly","year":"2010","journal-title":"Nat. Rev."},{"key":"2023012810251380600_btt037-B15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.tpj.6500226","article-title":"The HapMap project and its application to genetic studies of drug response","volume":"4","author":"Deloukas","year":"2004","journal-title":"Pharmacogenomics J."},{"key":"2023012810251380600_btt037-B16","first-page":"1708","article-title":"Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus","volume":"34","author":"Demirci","year":"2007","journal-title":"J. Rheumatol."},{"key":"2023012810251380600_btt037-B17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2105-10-180","article-title":"Seq4SNPs: new software for retrieval of multiple, accurately annotated DNA sequences, ready formatted for SNP assay design","volume":"10","author":"Field","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2023012810251380600_btt037-B18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/humu.20123","article-title":"PolyMAPr: programs for polymorphism database mining, annotation, and functional analysis","volume":"25","author":"Freimuth","year":"2005","journal-title":"Hum. Mutat."},{"key":"2023012810251380600_btt037-B19","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1407s23","article-title":"PharmGKB: an integrated resource of pharmacogenomic data and knowledge","author":"Gong","year":"2008","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"2023012810251380600_btt037-B20","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1124\/mol.104.009175","article-title":"EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information","volume":"67","author":"Hayes","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"2023012810251380600_btt037-B21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00008571-200312000-00007","article-title":"ADRIS\u2014the adverse drug reactions information scheme","volume":"13","author":"Hug","year":"2003","journal-title":"Pharmacogenetics"},{"key":"2023012810251380600_btt037-B22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/bioinformatics\/btp652","article-title":"The Gene Interaction Miner: a new tool for data mining contextual information for protein-protein interaction analysis","volume":"26","author":"Ikin","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B23","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8\u2013a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2165\/00002018-200326100-00002","article-title":"Drug Adverse Reaction Target Database (DART): proteins related to adverse drug reactions","volume":"26","author":"Ji","year":"2003","journal-title":"Drug Saf."},{"key":"2023012810251380600_btt037-B25","doi-asserted-by":"crossref","first-page":"D1035","DOI":"10.1093\/nar\/gkq1126","article-title":"DrugBank 3.0: a comprehensive resource for \u2018Omics' research on drugs","volume":"39","author":"Knox","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/00365520701682615","article-title":"Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease","volume":"43","author":"Kocsis","year":"2008","journal-title":"Scand. J. Gastroenterol."},{"key":"2023012810251380600_btt037-B27","doi-asserted-by":"crossref","first-page":"D552","DOI":"10.1093\/nar\/gkp937","article-title":"STITCH 2: an interaction network database for small molecules and proteins","volume":"38","author":"Kuhn","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B28","doi-asserted-by":"crossref","first-page":"D513","DOI":"10.1093\/nar\/gkp944","article-title":"GWIDD: genome-wide protein docking database","volume":"38","author":"Kundrotas","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/1479-7364-3-3-291","article-title":"Protein-protein interaction databases: keeping up with growing interactomes","volume":"3","author":"Lehne","year":"2009","journal-title":"Hum. Genomics"},{"key":"2023012810251380600_btt037-B30","first-page":"1","article-title":"SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women","volume":"91","author":"Lin","year":"2008","journal-title":"Chin. J. Physiol."},{"key":"2023012810251380600_btt037-B31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/omi.2008.0050","article-title":"Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan","volume":"13","author":"Lin","year":"2009","journal-title":"OMICS"},{"key":"2023012810251380600_btt037-B32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/bioinformatics\/btp697","article-title":"DCDB: drug combination database","volume":"26","author":"Liu","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B33","doi-asserted-by":"crossref","first-page":"D284","DOI":"10.1093\/nar\/gkn727","article-title":"MMsINC: a large-scale chemoinformatics database","volume":"37","author":"Masciocchi","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1289\/ehp.6028","article-title":"The Comparative Toxicogenomics Database (CTD)","volume":"111","author":"Mattingly","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"2023012810251380600_btt037-B35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jez.a.307","article-title":"The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies","volume":"305","author":"Mattingly","year":"2006","journal-title":"J. Exp. Zool. A Comp. Exp. Biol."},{"key":"2023012810251380600_btt037-B36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2105-9-146","article-title":"Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions","volume":"9","author":"Mechanic","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023012810251380600_btt037-B37","doi-asserted-by":"crossref","first-page":"W738","DOI":"10.1093\/nar\/gkl065","article-title":"FAF-Drugs: free ADME\/tox filtering of compound collections","volume":"34","author":"Miteva","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B38","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1021\/jm070533j","article-title":"Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methods","volume":"50","author":"Neugebauer","year":"2007","journal-title":"J. Med. Chem."},{"key":"2023012810251380600_btt037-B39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/humu.20731","article-title":"PharmGKB and the International Warfarin Pharmacogenetics Consortium: the changing role for pharmacogenomic databases and single-drug pharmacogenetics","volume":"29","author":"Owen","year":"2008","journal-title":"Hum Mutat"},{"key":"2023012810251380600_btt037-B40","doi-asserted-by":"crossref","first-page":"D617","DOI":"10.1093\/nar\/gkj151","article-title":"SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes","volume":"34","author":"Packer","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B41","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2217\/14622416.9.11.1573","article-title":"Ability of whole-genome SNP arrays to capture \u2018must have' pharmacogenomic variants","volume":"9","author":"Peters","year":"2008","journal-title":"Pharmacogenomics"},{"key":"2023012810251380600_btt037-B42","doi-asserted-by":"crossref","first-page":"D234","DOI":"10.1093\/nar\/gkp874","article-title":"REBASE\u2013a database for DNA restriction and modification: enzymes, genes and genomes","volume":"38","author":"Roberts","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-60327-411-1_7","article-title":"Pyrosequencing for SNP genotyping","volume":"578","author":"Royo","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"2023012810251380600_btt037-B44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2217\/14622416.6.7.749","article-title":"Large-scale databases in toxicogenomics","volume":"6","author":"Salter","year":"2005","journal-title":"Pharmacogenomics"},{"key":"2023012810251380600_btt037-B45","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/03602530802413338","article-title":"PharmGKB: understanding the effects of individual genetic variants","volume":"40","author":"Sangkuhl","year":"2008","journal-title":"Drug Metab. Rev."},{"key":"2023012810251380600_btt037-B46","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/bioinformatics\/btq068","article-title":"CandiSNPer: a web tool for the identification of candidate SNPs for causal variants","volume":"26","author":"Schmitt","year":"2010","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-60327-411-1_19","article-title":"The TaqMan method for SNP genotyping","volume":"578","author":"Shen","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"2023012810251380600_btt037-B48","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B49","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/bioinformatics\/18.12.1699","article-title":"ADME-AP: a database of ADME associated proteins","volume":"18","author":"Sun","year":"2002","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B50","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1101\/gr.4413105","article-title":"The International HapMap Project Web site","volume":"15","author":"Thorisson","year":"2005","journal-title":"Genome Res."},{"key":"2023012810251380600_btt037-B51","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/pgs.10.15","article-title":"Pharmacogenomics and bioinformatics: PharmGKB","volume":"11","author":"Thorn","year":"2010","journal-title":"Pharmacogenomics"},{"key":"2023012810251380600_btt037-B52","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.2174\/138945008786949379","article-title":"Drug-binding databases","volume":"9","author":"Timmers","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"2023012810251380600_btt037-B53","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1289\/ehp.6497","article-title":"ArrayTrack\u2013supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research","volume":"111","author":"Tong","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"2023012810251380600_btt037-B54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/157016308785739811","article-title":"SNP technologies for drug discovery: a current review","volume":"5","author":"Voisey","year":"2008","journal-title":"Curr. Drug Discov. Technol."},{"key":"2023012810251380600_btt037-B55","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1021\/ci700141x","article-title":"Chemical data mining of the NCI human tumor cell line database","volume":"47","author":"Wang","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"2023012810251380600_btt037-B56","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1093\/bioinformatics\/btp477","article-title":"PineSAP\u2013sequence alignment and SNP identification pipeline","volume":"25","author":"Wegrzyn","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B57","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1404s18","article-title":"In silico drug exploration and discovery using DrugBank","author":"Wishart","year":"2007","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"2023012810251380600_btt037-B58","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2217\/14622416.9.8.1155","article-title":"DrugBank and its relevance to pharmacogenomics","volume":"9","author":"Wishart","year":"2008","journal-title":"Pharmacogenomics"},{"key":"2023012810251380600_btt037-B59","doi-asserted-by":"crossref","first-page":"D901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: a knowledgebase for drugs, drug actions and drug targets","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B60","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/bioinformatics\/btk045","article-title":"Chemical effects in biological systems (CEBS) object model for toxicology data, SysTox-OM: design and application","volume":"22","author":"Xirasagar","year":"2006","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B61","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/omi.2008.0026","article-title":"SNP ID-info: SNP ID searching and visualization platform","volume":"12","author":"Yang","year":"2008","journal-title":"OMICS"},{"key":"2023012810251380600_btt037-B62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canep.2009.07.001","article-title":"Novel generating protective single nucleotide polymorphism barcode for breast cancer using particle swarm optimization","volume":"33","author":"Yang","year":"2009","journal-title":"Cancer Epidemiol."},{"key":"2023012810251380600_btt037-B63","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.kjms.2012.02.002","article-title":"Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms","volume":"28","author":"Yang","year":"2012","journal-title":"Kaohsiung J. Med. Sci."},{"key":"2023012810251380600_btt037-B64","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0714.2007.00608.x","article-title":"Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan","volume":"37","author":"Yen","year":"2008","journal-title":"J. Oral Pathol. Med."},{"key":"2023012810251380600_btt037-B65","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1440-1746.2008.05307.x","article-title":"Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer","volume":"23","author":"Yoshiya","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2023012810251380600_btt037-B66","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1093\/bioinformatics\/btp431","article-title":"Path: a tool to facilitate pathway-based genetic association analysis","volume":"25","author":"Zamar","year":"2009","journal-title":"Bioinformatics"},{"key":"2023012810251380600_btt037-B67","doi-asserted-by":"crossref","first-page":"D794","DOI":"10.1093\/nar\/gkl853","article-title":"PharmGED: pharmacogenetic effect database","volume":"35","author":"Zheng","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023012810251380600_btt037-B68","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1056\/NEJMoa075819","article-title":"Cumulative association of five genetic variants with prostate cancer","volume":"358","author":"Zheng","year":"2008","journal-title":"N Engl. J. Med."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/29\/6\/758\/48896695\/bioinformatics_29_6_758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/29\/6\/758\/48896695\/bioinformatics_29_6_758.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T11:58:03Z","timestamp":1674907083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/29\/6\/758\/183789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btt037","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,3,15]]},"published":{"date-parts":[[2013,2,15]]}}}