{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:13:55Z","timestamp":1771539235331,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Peptides play important roles in signalling, regulation and immunity within an organism. Many have successfully been used as therapeutic products often mimicking naturally occurring peptides. Here we present PeptideLocator for the automated prediction of functional peptides in a protein sequence.<\/jats:p>\n               <jats:p>Results: We have trained a machine learning algorithm to predict bioactive peptides within protein sequences. PeptideLocator performs well on training data achieving an area under the curve of 0.92 when tested in 5-fold cross-validation on a set of 2202 redundancy reduced peptide containing protein sequences. It has predictive power when applied to antimicrobial peptides, cytokines, growth factors, peptide hormones, toxins, venoms and other peptides. It can be applied to refine the choice of experimental investigations in functional studies of proteins.<\/jats:p>\n               <jats:p>Availability and implementation: PeptideLocator is freely available for academic users at http:\/\/bioware.ucd.ie\/.<\/jats:p>\n               <jats:p>Contact: \u00a0denis.shields@ucd.ie<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt103","type":"journal-article","created":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T00:54:39Z","timestamp":1363481679000},"page":"1120-1126","source":"Crossref","is-referenced-by-count":74,"title":["PeptideLocator: prediction of bioactive peptides in protein sequences"],"prefix":"10.1093","volume":"29","author":[{"given":"Catherine","family":"Mooney","sequence":"first","affiliation":[{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"}]},{"given":"Niall J.","family":"Haslam","sequence":"additional","affiliation":[{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"}]},{"given":"Th\u00e9r\u00e8se A.","family":"Holton","sequence":"additional","affiliation":[{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"}]},{"given":"Gianluca","family":"Pollastri","sequence":"additional","affiliation":[{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"}]},{"given":"Denis C.","family":"Shields","sequence":"additional","affiliation":[{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"1 Complex and Adaptive Systems Laboratory, 2Conway Institute of Biomolecular and Biomedical Science, 3School of Medicine and Medical Science, 4Food For Health Ireland and 5School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland"}]}],"member":"286","published-online":{"date-parts":[[2013,3,16]]},"reference":[{"key":"2023012810304576700_btt103-B1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/abbi.2000.1824","article-title":"Characterization of two novel defense peptides from pea Pisum sativum seeds","volume":"378","author":"Almeida","year":"2000","journal-title":"Arch. 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