{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:21:17Z","timestamp":1772821277933,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Exome capture kits have capture efficiencies that range from 40 to 60%. A significant amount of off-target reads are from the mitochondrial genome. These unintentionally sequenced mitochondrial reads provide unique opportunities to study the mitochondria genome.<\/jats:p>\n               <jats:p>Results: MitoSeek is an open-source software tool that can reliably and easily extract mitochondrial genome information from exome and whole genome sequencing data. MitoSeek evaluates mitochondrial genome alignment quality, estimates relative mitochondrial copy numbers and detects heteroplasmy, somatic mutation and structural variants of the mitochondrial genome. MitoSeek can be set up to run in parallel or serial on large exome sequencing datasets.<\/jats:p>\n               <jats:p>Availability: https:\/\/github.com\/riverlee\/MitoSeek<\/jats:p>\n               <jats:p>Contact: yan.guo@vanderbilt.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt118","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T02:22:13Z","timestamp":1362709333000},"page":"1210-1211","source":"Crossref","is-referenced-by-count":82,"title":["MitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis"],"prefix":"10.1093","volume":"29","author":[{"given":"Yan","family":"Guo","sequence":"first","affiliation":[{"name":"1 Center for Quantitative Sciences, Vanderbilt University, 2220 Pierce Ave, 571 Preston Research Building and 2Center for Human Genetics Research, Vanderbilt University, 507B Light Hall, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"1 Center for Quantitative Sciences, Vanderbilt University, 2220 Pierce Ave, 571 Preston Research Building and 2Center for Human Genetics Research, Vanderbilt University, 507B Light Hall, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-I","family":"Li","sequence":"additional","affiliation":[{"name":"1 Center for Quantitative Sciences, Vanderbilt University, 2220 Pierce Ave, 571 Preston Research Building and 2Center for Human Genetics Research, Vanderbilt University, 507B Light Hall, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shyr","sequence":"additional","affiliation":[{"name":"1 Center for Quantitative Sciences, Vanderbilt University, 2220 Pierce Ave, 571 Preston Research Building and 2Center for Human Genetics Research, Vanderbilt University, 507B Light Hall, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Samuels","sequence":"additional","affiliation":[{"name":"1 Center for Quantitative Sciences, Vanderbilt University, 2220 Pierce Ave, 571 Preston Research Building and 2Center for Human Genetics Research, Vanderbilt University, 507B Light Hall, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,3,6]]},"reference":[{"key":"2023012810365843000_btt118-B1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/13779","article-title":"Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA","volume":"23","author":"Andrews","year":"1999","journal-title":"Nat. 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