{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T03:05:46Z","timestamp":1767409546832},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Local ancestry analysis of genotype data from recently admixed populations (e.g. Latinos, African Americans) provides key insights into population history and disease genetics. Although methods for local ancestry inference have been extensively validated in simulations (under many unrealistic assumptions), no empirical study of local ancestry accuracy in Latinos exists to date. Hence, interpreting findings that rely on local ancestry in Latinos is challenging.<\/jats:p>\n               <jats:p>Results: Here, we use 489 nuclear families from the mainland USA, Puerto Rico and Mexico in conjunction with 3204 unrelated Latinos from the Multiethnic Cohort study to provide the first empirical characterization of local ancestry inference accuracy in Latinos. Our approach for identifying errors does not rely on simulations but on the observation that local ancestry in families follows Mendelian inheritance. We measure the rate of local ancestry assignments that lead to Mendelian inconsistencies in local ancestry in trios (MILANC), which provides a lower bound on errors in the local ancestry estimates. We show that MILANC rates observed in simulations underestimate the rate observed in real data, and that MILANC varies substantially across the genome. Second, across a wide range of methods, we observe that loci with large deviations in local ancestry also show enrichment in MILANC rates. Therefore, local ancestry estimates at such loci should be interpreted with caution. Finally, we reconstruct ancestral haplotype panels to be used as reference panels in local ancestry inference and show that ancestry inference is significantly improved by incoroprating these reference panels.<\/jats:p>\n               <jats:p>Availability and implementation: We provide the reconstructed reference panels together with the maps of MILANC rates as a public resource for researchers analyzing local ancestry in Latinos at http:\/\/bogdanlab.pathology.ucla.edu.<\/jats:p>\n               <jats:p>Contact: \u00a0bpasaniuc@mednet.ucla.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt166","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T02:22:46Z","timestamp":1365560566000},"page":"1407-1415","source":"Crossref","is-referenced-by-count":39,"title":["Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation"],"prefix":"10.1093","volume":"29","author":[{"given":"Bogdan","family":"Pasaniuc","sequence":"first","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Sriram","family":"Sankararaman","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Dara G.","family":"Torgerson","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Christopher","family":"Gignoux","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Noah","family":"Zaitlen","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Celeste","family":"Eng","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"William","family":"Rodriguez-Cintron","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Rocio","family":"Chapela","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Jean G.","family":"Ford","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Pedro C.","family":"Avila","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Jose","family":"Rodriguez-Santana","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Gary K.","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Loic","family":"Le Marchand","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Brian","family":"Henderson","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"David","family":"Reich","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Christopher A.","family":"Haiman","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Esteban","family":"Gonz\u00e0lez Burchard","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]},{"given":"Eran","family":"Halperin","sequence":"additional","affiliation":[{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"},{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"},{"name":"1 Department of Pathology and Molecular Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 10833, 2Department of Genetics, Harvard Medical School, Boston, MA 02115, 3Departments of Bioengineering and Therapeutic Sciences and Medicine, University of California, San Francisco, CA 94143, USA, 4Veterans Caribbean Health Care System, San Juan, Puerto Rico 00921, 5Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico 14080, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA, 7Division of Allergy-Immunology, Northwestern University, Chicago, IL 60611, USA, 8Centro de Neumologia Pediatrica, CSP, San Juan, Puerto Rico 00917, 9Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA, 10Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA, 11The Blavatnik School of Computer Science, Tel-Aviv University, 1"}]}],"member":"286","published-online":{"date-parts":[[2013,4,9]]},"reference":[{"key":"2023062610155397600_btt166-B1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature09298","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"key":"2023062610155397600_btt166-B2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/bioinformatics\/bts144","article-title":"Fast and accurate inference of local ancestry in latino 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