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To overcome this limitation, we present CellH5, an HDF5 data format for cell-based assays in high-throughput microscopy, which stores high-dimensional image data along with inter-object relations in graphs. CellH5Browser, an interactive gallery image browser, demonstrates the versatility and performance of the file format on live imaging data of dividing human cells. CellH5 provides new opportunities for integrated data analysis by multiple software platforms.<\/jats:p>\n               <jats:p>Availability: Source code is freely available at www.github.com\/cellh5 under the GPL license and at www.bioconductor.org\/packages\/release\/bioc\/html\/rhdf5.html under the Artistic-2.0 license. Demo datasets and the CellH5Browser are available at www.cellh5.org. A Fiji importer for cellh5 will be released soon.<\/jats:p>\n               <jats:p>Contact: \u00a0daniel.gerlich@imba.oeaw.ac.at or christoph.sommer@imba.oeaw.ac.at<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt175","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T01:03:27Z","timestamp":1366247007000},"page":"1580-1582","source":"Crossref","is-referenced-by-count":15,"title":["CellH5: a format for data exchange in high-content screening"],"prefix":"10.1093","volume":"29","author":[{"given":"Christoph","family":"Sommer","sequence":"first","affiliation":[{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"},{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Held","sequence":"additional","affiliation":[{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Fischer","sequence":"additional","affiliation":[{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Huber","sequence":"additional","affiliation":[{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Gerlich","sequence":"additional","affiliation":[{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"},{"name":"1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria, 2Institute of Biochemistry, Department of Biology Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland and 3Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"2023012810440813600_btt175-B1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/bioinformatics\/17.12.1213","article-title":"A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells","volume":"17","author":"Boland","year":"2001","journal-title":"Bioinformatics"},{"key":"2023012810440813600_btt175-B2","first-page":"501","article-title":"Graphml progress report: structural layer proposal","volume-title":"Proceedings of 9th International Symposium on Graph Drawing","author":"Brandes","year":"2001"},{"key":"2023012810440813600_btt175-B3","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"2023012810440813600_btt175-B4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.200910105","article-title":"Automated microscopy for high-content RNAi screening","volume":"188","author":"Conrad","year":"2010","journal-title":"J. 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