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PAUDA requires &amp;lt;80 CPU hours to analyze a dataset of 246 million Illumina DNA reads from permafrost soil for which a previous BLASTX analysis (on a subset of 176 million reads) reportedly required 800 000 CPU hours, leading to the same clustering of samples by functional profiles.<\/jats:p>\n               <jats:p>Availability: PAUDA is freely available from: http:\/\/ab.inf.uni-tuebingen.de\/software\/pauda. Also supplementary method details are available from this website.<\/jats:p>\n               <jats:p>Contact: \u00a0daniel.huson@uni-tuebingen.de or xiechao@bic.nus.edu.sg<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt254","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:53:51Z","timestamp":1368060831000},"page":"38-39","source":"Crossref","is-referenced-by-count":49,"title":["A poor man\u2019s BLASTX\u2014high-throughput metagenomic protein database search using PAUDA"],"prefix":"10.1093","volume":"30","author":[{"given":"Daniel H.","family":"Huson","sequence":"first","affiliation":[{"name":"1 Singapore Centre on Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore 637551, 2Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany and 3Life Sciences Institute, National University of Singapore, Singapore 117456"},{"name":"1 Singapore Centre on Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore 637551, 2Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany and 3Life Sciences Institute, National University of Singapore, Singapore 117456"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xie","sequence":"additional","affiliation":[{"name":"1 Singapore Centre on Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore 637551, 2Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany and 3Life Sciences Institute, National University of Singapore, Singapore 117456"},{"name":"1 Singapore Centre on Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore 637551, 2Center for Bioinformatics, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany and 3Life Sciences Institute, National University of Singapore, Singapore 117456"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"2023012710380182700_btt254-B1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. 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