{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:13:00Z","timestamp":1676977980566},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The development of computational tools to enable testing and analysis of high-throughput\u2013sequencing data is essential to modern genomics research. However, although multiple frameworks have been developed to facilitate access to these tools, comparatively little effort has been made at implementing low-level programming libraries to increase the speed and ease of their development.<\/jats:p>\n               <jats:p>Results: We propose NGS++, a programming library in C++11 specialized in manipulating both next-generation sequencing (NGS) datasets and genomic information files. This library allows easy integration of new formats and rapid prototyping of new functionalities with a focus on the analysis of genomic regions and features. It offers a powerful, yet versatile and easily extensible interface to read, write and manipulate multiple genomic file formats. By standardizing the internal data structures and presenting a common interface to the data parser, NGS++ offers an effective framework for epigenomics tool development.<\/jats:p>\n               <jats:p>Availability: NGS++ was written in C++ using the C++11 standard. It requires minimal efforts to build and is well-documented via a complete docXygen guide, online documentation and tutorials. Source code, tests, code examples and documentation are available via the website at http:\/\/www.ngsplusplus.ca and the github repository at https:\/\/github.com\/NGS-lib\/NGSplusplus.<\/jats:p>\n               <jats:p>Contact: \u00a0nicolas.gevry@usherbrooke.ca or arnaud.droit@crchuq.ulaval.ca<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt312","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T02:31:51Z","timestamp":1370399511000},"page":"1893-1894","source":"Crossref","is-referenced-by-count":4,"title":["NGS++: a library for rapid prototyping of epigenomics software tools"],"prefix":"10.1093","volume":"29","author":[{"given":"Alexei","family":"Nordell Markovits","sequence":"first","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Joly Beauparlant","sequence":"additional","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Toupin","sequence":"additional","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengrui","family":"Wang","sequence":"additional","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Droit","sequence":"additional","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Gevry","sequence":"additional","affiliation":[{"name":"1 Department of Biology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec J1K 2R1, 2Department of Molecular Medicine, Centre de Recherche du CHU de Quebec, Universit\u00e9 Laval, Quebec, Quebec G1V 4G2 and 3Department of Computer Science, Universit\u00e9 de Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"2023012810444663000_btt312-B1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/bioinformatics\/btr174","article-title":"BamTools: a C++ API and toolkit for analyzing and managing BAM files","volume":"27","author":"Barnett","year":"2011","journal-title":"Bioinformatics"},{"key":"2023012810444663000_btt312-B2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1109\/99.660313","article-title":"OpenMP: an industry standard API for shared-memory programming","volume":"5","author":"Dagum","year":"1998","journal-title":"IEEE Comput. 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