{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:34:33Z","timestamp":1761708873893},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1212,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: DMEAS is the first user-friendly tool dedicated to analyze the distribution of DNA methylation patterns for the quantification of epigenetic heterogeneity. It supports the analysis of both locus-specific and genome-wide bisulfite sequencing data. DMEAS progressively scans the mapping results of bisulfite sequencing reads to extract DNA methylation patterns for contiguous CpG dinucleotides. It determines the DNA methylation level and calculates methylation entropy for genomic segments to enable the quantitative assessment of DNA methylation variations observed in cell populations.<\/jats:p>\n               <jats:p>Availability and implementation: DMEAS program, user guide and all the testing data are freely available from http:\/\/sourceforge.net\/projects\/dmeas\/files\/<\/jats:p>\n               <jats:p>Contact: \u00a0davidxie@vt.edu<\/jats:p>\n               <jats:p>Supplementary Information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt332","type":"journal-article","created":{"date-parts":[[2013,6,9]],"date-time":"2013-06-09T00:54:20Z","timestamp":1370739260000},"page":"2044-2045","source":"Crossref","is-referenced-by-count":21,"title":["DMEAS: DNA methylation entropy analysis software"],"prefix":"10.1093","volume":"29","author":[{"given":"Jianlin","family":"He","sequence":"first","affiliation":[{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"}]},{"given":"Xinxi","family":"Sun","sequence":"additional","affiliation":[{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"},{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"}]},{"given":"Xiaojian","family":"Shao","sequence":"additional","affiliation":[{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"}]},{"given":"Liji","family":"Liang","sequence":"additional","affiliation":[{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"}]},{"given":"Hehuang","family":"Xie","sequence":"additional","affiliation":[{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"},{"name":"1 Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China and 2Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA"}]}],"member":"286","published-online":{"date-parts":[[2013,6,8]]},"reference":[{"key":"2023020305301491800_btt332-B1","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"2023020305301491800_btt332-B2","doi-asserted-by":"crossref","first-page":"W551","DOI":"10.1093\/nar\/gkr312","article-title":"BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing","volume":"39","author":"Lutsik","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023020305301491800_btt332-B3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2105-11-230","article-title":"BISMA\u2013fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences","volume":"11","author":"Rohde","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023020305301491800_btt332-B4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.1222361","article-title":"Cancer. 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