{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:24:22Z","timestamp":1778883862450,"version":"3.51.4"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1213,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary:\u2003The Network Ontology Analysis (NOA) plugin for Cytoscape implements the NOA algorithm for network-based enrichment analysis, which extends Gene Ontology annotations to network links, or edges. The plugin facilitates the annotation and analysis of one or more networks in Cytoscape according to user-defined parameters. In addition to tables, the NOA plugin also presents results in the form of heatmaps and overview networks in Cytoscape, which can be exported for publication figures.<\/jats:p>\n               <jats:p>Availability:\u2003The NOA plugin is an open source, Java program for Cytoscape version 2.8 available via the Cytoscape App Store (http:\/\/apps.cytoscape.org\/apps\/noa) and plugin manager. A detailed user manual is available at http:\/\/nrnb.org\/tools\/noa.<\/jats:p>\n               <jats:p>Contact:\u2003apico@gladstone.ucsf.edu<\/jats:p>\n               <jats:p>Supplementary information:\u2003Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt334","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T01:09:41Z","timestamp":1370653781000},"page":"2066-2067","source":"Crossref","is-referenced-by-count":24,"title":["NOA: a cytoscape plugin for network ontology analysis"],"prefix":"10.1093","volume":"29","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiguang","family":"Wang","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"},{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"},{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Hanspers","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luonan","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and Christopher S. 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Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA, 2Beijing Institute of Genomics, 100029 and 3Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China, 4Gladstone Institutes, San Francisco, CA 94158, USA and 5Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"2023020305202772100_btt334-B1","doi-asserted-by":"crossref","first-page":"D1301","DOI":"10.1093\/nar\/gkr1074","article-title":"WikiPathways: building research communities on biological pathways","volume":"40","author":"Kelder","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023020305202772100_btt334-B2","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"2023020305202772100_btt334-B3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2105-11-5","article-title":"The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services","volume":"11","author":"van Iersel","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023020305202772100_btt334-B4","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1093\/nar\/gkr251","article-title":"NOA: a novel Network Ontology Analysis method","volume":"39","author":"Wang","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023020305202772100_btt334-B5","doi-asserted-by":"crossref","first-page":"e1000521","DOI":"10.1371\/journal.pcbi.1000521","article-title":"Disease-aging network reveals significant roles of aging genes in connecting genetic diseases","volume":"5","author":"Wang","year":"2009","journal-title":"PLoS Comput. 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