{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:40:30Z","timestamp":1767962430849,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Large numbers of long intergenic non-coding RNA (lincRNA) have been detected through high-throughput sequencing technology. However, currently we still know very little about their functions. Therefore, a lincRNA function annotation database is needed to facilitate the study in this field. In this article, we present Linc2GO, a web resource that aims to provide comprehensive functional annotations for human lincRNA. MicroRNA-mRNA and microRNA-lincRNA interaction data were integrated to generate lincRNA functional annotations based on the \u2018competing endogenous RNA hypothesis\u2019. To the best of our knowledge, Linc2GO is the first database that makes use of the \u2018competing endogenous RNA hypothesis\u2019 to predict lincRNA functions.<\/jats:p>\n               <jats:p>Availability: Freely available at http:\/\/www.bioinfo.tsinghua.edu.cn\/~liuke\/Linc2GO\/index.html<\/jats:p>\n               <jats:p>Contact: \u00a0sunzhr@mail.tsinghua.edu.cn<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt361","type":"journal-article","created":{"date-parts":[[2013,6,23]],"date-time":"2013-06-23T00:20:14Z","timestamp":1371946814000},"page":"2221-2222","source":"Crossref","is-referenced-by-count":100,"title":["Linc2GO: a human LincRNA function annotation resource based on ceRNA hypothesis"],"prefix":"10.1093","volume":"29","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China"}]},{"given":"Zhangming","family":"Yan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China"}]},{"given":"Yuchao","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China"}]},{"given":"Zhirong","family":"Sun","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China"}]}],"member":"286","published-online":{"date-parts":[[2013,6,22]]},"reference":[{"key":"2023012810462234500_btt361-B1","first-page":"11","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, 116, 281\u2013297, 2004)","volume":"131","author":"Bartel","year":"2007","journal-title":"Cell"},{"key":"2023012810462234500_btt361-B2","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol."},{"key":"2023012810462234500_btt361-B3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev."},{"key":"2023012810462234500_btt361-B4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2011.09.028","article-title":"A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA (erratum Cell, 147, 948)","volume":"147","author":"Cesana","year":"2011","journal-title":"Cell"},{"key":"2023012810462234500_btt361-B5","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1093\/nar\/gks967","article-title":"Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks","volume":"41","author":"Guo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023012810462234500_btt361-B6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"2023012810462234500_btt361-B7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10398","article-title":"lincRNAs act in the circuitry controlling pluripotency and differentiation","volume":"477","author":"Guttman","year":"2011","journal-title":"Nature"},{"key":"2023012810462234500_btt361-B8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nature10887","article-title":"Modular regulatory principles of large non-coding RNAs","volume":"482","author":"Guttman","year":"2012","journal-title":"Nature"},{"key":"2023012810462234500_btt361-B9","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat. 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